Human Gene SERPINB8 (ENST00000397985.7) from GENCODE V44
Description: Homo sapiens serpin family B member 8 (SERPINB8), transcript variant 2, mRNA. (from RefSeq NM_198833) RefSeq Summary (NM_002640): The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]. Gencode Transcript: ENST00000397985.7 Gencode Gene: ENSG00000166401.15 Transcript (Including UTRs) Position: hg38 chr18:63,970,081-63,989,374 Size: 19,294 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr18:63,978,309-63,987,278 Size: 8,970 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50452
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
