Human Gene SHC2 (ENST00000264554.11) from GENCODE V44
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: SHC2_HUMAN
DESCRIPTION: RecName: Full=SHC-transforming protein 2; AltName: Full=Protein Sck; AltName: Full=SHC-transforming protein B; AltName: Full=Src homology 2 domain-containing-transforming protein C2; Short=SH2 domain protein C2;
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). SUBUNIT: Interacts with the Trk receptors in a phosphotyrosine- dependent manner and MEGF12. Once activated, binds to GRB2. TISSUE SPECIFICITY: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. DOMAIN: The PID domain mediates binding to the TrkA receptor. PTM: Phosphorylated on tyrosines by the Trk receptors. MISCELLANEOUS: PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576. SIMILARITY: Contains 1 PID domain. SIMILARITY: Contains 1 SH2 domain.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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Press "+" in the title bar above to open this section.
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_dom
IPR006019 - PID_domain
IPR006020 - PTyr_interaction_dom
IPR000980 - SH2
Pfam Domains: PF00640 - Phosphotyrosine interaction domain (PTB/PID)
PF00017 - SH2 domain
ModBase Predicted Comparative 3D Structure on P98077
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC048290 - Homo sapiens, Similar to src homology 2 domain-containing transforming protein C3, clone IMAGE:5210500, mRNA. BC030527 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 2, mRNA (cDNA clone IMAGE:5208505), with apparent retained intron. BC034544 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 2, mRNA (cDNA clone IMAGE:4752153), with apparent retained intron. AL360254 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 979979. AB001451 - Homo sapiens mRNA for Sck, partial cds. JD489861 - Sequence 470885 from Patent EP1572962. JD279683 - Sequence 260707 from Patent EP1572962. JD058395 - Sequence 39419 from Patent EP1572962. JD078519 - Sequence 59543 from Patent EP1572962. JD373444 - Sequence 354468 from Patent EP1572962. JD116301 - Sequence 97325 from Patent EP1572962. JD515389 - Sequence 496413 from Patent EP1572962. JD210402 - Sequence 191426 from Patent EP1572962. JD149567 - Sequence 130591 from Patent EP1572962. JD040799 - Sequence 21823 from Patent EP1572962. JD398916 - Sequence 379940 from Patent EP1572962. JD400717 - Sequence 381741 from Patent EP1572962. JD399818 - Sequence 380842 from Patent EP1572962. JD335833 - Sequence 316857 from Patent EP1572962. JD464792 - Sequence 445816 from Patent EP1572962. JD336292 - Sequence 317316 from Patent EP1572962. BC156898 - Synthetic construct Homo sapiens clone IMAGE:100062768, MGC:190608 SHC (Src homology 2 domain containing) transforming protein 2 (SHC2) mRNA, encodes complete protein. BC156109 - Synthetic construct Homo sapiens clone IMAGE:100062361, MGC:190483 SHC (Src homology 2 domain containing) transforming protein 2 (SHC2) mRNA, encodes complete protein. JD102506 - Sequence 83530 from Patent EP1572962. JD057886 - Sequence 38910 from Patent EP1572962. JD216646 - Sequence 197670 from Patent EP1572962. AK128825 - Homo sapiens cDNA FLJ46268 fis, clone TESTI4027262. JD055054 - Sequence 36078 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000264554.1, ENST00000264554.10, ENST00000264554.2, ENST00000264554.3, ENST00000264554.4, ENST00000264554.5, ENST00000264554.6, ENST00000264554.7, ENST00000264554.8, ENST00000264554.9, NM_012435, O60230, P98077, Q9NPL5, Q9UCX4, SCK, SHC2_HUMAN, SHCB, uc002loq.1, uc002loq.2, uc002loq.3, uc002loq.4, uc002loq.5 UCSC ID: ENST00000264554.11 RefSeq Accession: NM_012435
Protein: P98077
(aka SHC2_HUMAN)
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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