Human Gene SHC2 (ENST00000264554.11) from GENCODE V44
  Description: Homo sapiens SHC adaptor protein 2 (SHC2), mRNA. (from RefSeq NM_012435)
Gencode Transcript: ENST00000264554.11
Gencode Gene: ENSG00000129946.11
Transcript (Including UTRs)
   Position: hg38 chr19:416,589-461,033 Size: 44,445 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr19:418,928-460,996 Size: 42,069 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:416,589-461,033)mRNA (may differ from genome)Protein (582 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SHC2_HUMAN
DESCRIPTION: RecName: Full=SHC-transforming protein 2; AltName: Full=Protein Sck; AltName: Full=SHC-transforming protein B; AltName: Full=Src homology 2 domain-containing-transforming protein C2; Short=SH2 domain protein C2;
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
SUBUNIT: Interacts with the Trk receptors in a phosphotyrosine- dependent manner and MEGF12. Once activated, binds to GRB2.
TISSUE SPECIFICITY: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
DOMAIN: The PID domain mediates binding to the TrkA receptor.
PTM: Phosphorylated on tyrosines by the Trk receptors.
MISCELLANEOUS: PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.
SIMILARITY: Contains 1 PID domain.
SIMILARITY: Contains 1 SH2 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 67.59 RPKM in Pancreas
Total median expression: 987.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.5037-0.527 Picture PostScript Text
3' UTR -339.70739-0.460 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR006019 - PID_domain
IPR006020 - PTyr_interaction_dom
IPR000980 - SH2

Pfam Domains:
PF00640 - Phosphotyrosine interaction domain (PTB/PID)
PF00017 - SH2 domain

ModBase Predicted Comparative 3D Structure on P98077
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265 Ras protein signal transduction
GO:0035556 intracellular signal transduction
GO:0048010 vascular endothelial growth factor receptor signaling pathway

Cellular Component:
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC048290 - Homo sapiens, Similar to src homology 2 domain-containing transforming protein C3, clone IMAGE:5210500, mRNA.
BC030527 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 2, mRNA (cDNA clone IMAGE:5208505), with apparent retained intron.
BC034544 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 2, mRNA (cDNA clone IMAGE:4752153), with apparent retained intron.
AL360254 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 979979.
AB001451 - Homo sapiens mRNA for Sck, partial cds.
JD489861 - Sequence 470885 from Patent EP1572962.
JD279683 - Sequence 260707 from Patent EP1572962.
JD058395 - Sequence 39419 from Patent EP1572962.
JD078519 - Sequence 59543 from Patent EP1572962.
JD373444 - Sequence 354468 from Patent EP1572962.
JD116301 - Sequence 97325 from Patent EP1572962.
JD515389 - Sequence 496413 from Patent EP1572962.
JD210402 - Sequence 191426 from Patent EP1572962.
JD149567 - Sequence 130591 from Patent EP1572962.
JD040799 - Sequence 21823 from Patent EP1572962.
JD398916 - Sequence 379940 from Patent EP1572962.
JD400717 - Sequence 381741 from Patent EP1572962.
JD399818 - Sequence 380842 from Patent EP1572962.
JD335833 - Sequence 316857 from Patent EP1572962.
JD464792 - Sequence 445816 from Patent EP1572962.
JD336292 - Sequence 317316 from Patent EP1572962.
BC156898 - Synthetic construct Homo sapiens clone IMAGE:100062768, MGC:190608 SHC (Src homology 2 domain containing) transforming protein 2 (SHC2) mRNA, encodes complete protein.
BC156109 - Synthetic construct Homo sapiens clone IMAGE:100062361, MGC:190483 SHC (Src homology 2 domain containing) transforming protein 2 (SHC2) mRNA, encodes complete protein.
JD102506 - Sequence 83530 from Patent EP1572962.
JD057886 - Sequence 38910 from Patent EP1572962.
JD216646 - Sequence 197670 from Patent EP1572962.
AK128825 - Homo sapiens cDNA FLJ46268 fis, clone TESTI4027262.
JD055054 - Sequence 36078 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P98077 (Reactome details) participates in the following event(s):

R-HSA-4420107 p-6Y-VEGFR2 binds SHC-transforming protein 2
R-HSA-167056 SHC binds to the activated TrkA receptor
R-HSA-5685366 GRB2-1:SOS1 binds p-Y-SHC
R-HSA-167217 Phospho-Shc dissociates from the TrkA receptor
R-HSA-167019 SHC, complexed with TrkA, is tyrosine-phosphorylated
R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-167044 Signalling to RAS
R-HSA-194138 Signaling by VEGF
R-HSA-187687 Signalling to ERKs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000264554.1, ENST00000264554.10, ENST00000264554.2, ENST00000264554.3, ENST00000264554.4, ENST00000264554.5, ENST00000264554.6, ENST00000264554.7, ENST00000264554.8, ENST00000264554.9, NM_012435, O60230, P98077, Q9NPL5, Q9UCX4, SCK, SHC2_HUMAN, SHCB, uc002loq.1, uc002loq.2, uc002loq.3, uc002loq.4, uc002loq.5
UCSC ID: ENST00000264554.11
RefSeq Accession: NM_012435
Protein: P98077 (aka SHC2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.