Human Gene DAZAP1 (ENST00000233078.9) from GENCODE V44
Description: Homo sapiens DAZ associated protein 1 (DAZAP1), transcript variant 2, mRNA. (from RefSeq NM_018959) RefSeq Summary (NM_018959): In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000233078.9 Gencode Gene: ENSG00000071626.17 Transcript (Including UTRs) Position: hg38 chr19:1,407,586-1,435,684 Size: 28,099 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr19:1,407,774-1,434,912 Size: 27,139 Coding Exon Count: 12
ID:DAZP1_HUMAN DESCRIPTION: RecName: Full=DAZ-associated protein 1; AltName: Full=Deleted in azoospermia-associated protein 1; FUNCTION: RNA-binding protein, which may be required during spermatogenesis. SUBUNIT: Interacts with DAZ and DAZL. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity). TISSUE SPECIFICITY: Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=BAB71295.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96EP5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
