Human Gene BRD4 (ENST00000263377.6) Description and Page Index
Description: Homo sapiens bromodomain containing 4 (BRD4), transcript variant long, mRNA. (from RefSeq NM_058243) RefSeq Summary (NM_058243): The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000263377.6 Gencode Gene: ENSG00000141867.17 Transcript (Including UTRs) Position: hg38 chr19:15,235,519-15,280,451 Size: 44,933 Total Exon Count: 20 Strand: - Coding Region Position: hg38 chr19:15,238,377-15,273,099 Size: 34,723 Coding Exon Count: 19
ID:BRD4_HUMAN DESCRIPTION: RecName: Full=Bromodomain-containing protein 4; AltName: Full=Protein HUNK1; FUNCTION: Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). SUBUNIT: Associated with chromosomes during mitosis (By similarity). Interacts with bovine papillomavirus type 1 regulatory protein E2. INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-723869, EBI-401755; P16333:NCK1; NbExp=2; IntAct=EBI-723869, EBI-389883; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. DISEASE: Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein. SIMILARITY: Contains 2 bromo domains. SIMILARITY: Contains 1 NET domain. SEQUENCE CAUTION: Sequence=AAC27978.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BRD4ID837ch19p13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60885
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0006325 chromatin organization GO:0006338 chromatin remodeling GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0016032 viral process GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050727 regulation of inflammatory response GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain GO:2000002 negative regulation of DNA damage checkpoint