Human Gene TPM4 (ENST00000344824.11) from GENCODE V44
Description: tropomyosin 4 (from HGNC TPM4) RefSeq Summary (NM_003290): This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]. Gencode Transcript: ENST00000344824.11 Gencode Gene: ENSG00000167460.17 Transcript (Including UTRs) Position: hg38 chr19:16,079,502-16,102,149 Size: 22,648 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr19:16,086,427-16,101,346 Size: 14,920 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.