Human Gene MPV17L2 (ENST00000599612.3) from GENCODE V44
  Description: Homo sapiens MPV17 mitochondrial inner membrane protein like 2 (MPV17L2), mRNA. (from RefSeq NM_032683)
Gencode Transcript: ENST00000599612.3
Gencode Gene: ENSG00000254858.10
Transcript (Including UTRs)
   Position: hg38 chr19:18,193,218-18,196,948 Size: 3,731 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr19:18,193,282-18,196,055 Size: 2,774 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:18,193,218-18,196,948)mRNA (may differ from genome)Protein (206 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: M17L2_HUMAN
DESCRIPTION: RecName: Full=Mpv17-like protein 2;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.39 RPKM in Adrenal Gland
Total median expression: 383.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.0064-0.391 Picture PostScript Text
3' UTR -322.60893-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007248 - Mpv17_PMP22

Pfam Domains:
PF04117 - Mpv17 / PMP22 family

ModBase Predicted Comparative 3D Structure on Q567V2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0061668 mitochondrial ribosome assembly
GO:0070131 positive regulation of mitochondrial translation

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF384384 - JP 2014500723-A/191887: Polycomb-Associated Non-Coding RNAs.
MA619961 - JP 2018138019-A/191887: Polycomb-Associated Non-Coding RNAs.
BC093008 - Homo sapiens hypothetical protein MGC12972, mRNA (cDNA clone MGC:110861 IMAGE:30335716), complete cds.
BC005064 - Homo sapiens hypothetical protein MGC12972, mRNA (cDNA clone MGC:12972 IMAGE:3345778), complete cds.
BC028146 - Homo sapiens hypothetical protein MGC12972, mRNA (cDNA clone IMAGE:5217853), with apparent retained intron.
AF320622 - Homo sapiens FKSG24 (FKSG24) mRNA, complete cds.
AF416712 - Homo sapiens clone 1 unknown mRNA.
AK094091 - Homo sapiens cDNA FLJ36772 fis, clone ADRGL2000064.
JF432586 - Synthetic construct Homo sapiens clone IMAGE:100073823 hypothetical protein MGC12972 (FKSG24) gene, encodes complete protein.
LF372684 - JP 2014500723-A/180187: Polycomb-Associated Non-Coding RNAs.
MA608261 - JP 2018138019-A/180187: Polycomb-Associated Non-Coding RNAs.
LF372683 - JP 2014500723-A/180186: Polycomb-Associated Non-Coding RNAs.
MA608260 - JP 2018138019-A/180186: Polycomb-Associated Non-Coding RNAs.
LF208136 - JP 2014500723-A/15639: Polycomb-Associated Non-Coding RNAs.
MA443713 - JP 2018138019-A/15639: Polycomb-Associated Non-Coding RNAs.
JD424435 - Sequence 405459 from Patent EP1572962.
JD061103 - Sequence 42127 from Patent EP1572962.
JD126496 - Sequence 107520 from Patent EP1572962.
JD289892 - Sequence 270916 from Patent EP1572962.
JD108649 - Sequence 89673 from Patent EP1572962.
JD309503 - Sequence 290527 from Patent EP1572962.
JD322853 - Sequence 303877 from Patent EP1572962.
JD479258 - Sequence 460282 from Patent EP1572962.
JD515520 - Sequence 496544 from Patent EP1572962.
JD155143 - Sequence 136167 from Patent EP1572962.
JD076102 - Sequence 57126 from Patent EP1572962.
JD404885 - Sequence 385909 from Patent EP1572962.
JD454121 - Sequence 435145 from Patent EP1572962.
JD376114 - Sequence 357138 from Patent EP1572962.
JD252137 - Sequence 233161 from Patent EP1572962.
JD238645 - Sequence 219669 from Patent EP1572962.
JD343856 - Sequence 324880 from Patent EP1572962.
JD343857 - Sequence 324881 from Patent EP1572962.
JD496426 - Sequence 477450 from Patent EP1572962.
JD469017 - Sequence 450041 from Patent EP1572962.
JD170265 - Sequence 151289 from Patent EP1572962.
JD522584 - Sequence 503608 from Patent EP1572962.
JD179566 - Sequence 160590 from Patent EP1572962.
LF213749 - JP 2014500723-A/21252: Polycomb-Associated Non-Coding RNAs.
MA449326 - JP 2018138019-A/21252: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000599612.1, ENST00000599612.2, FKSG24, M17L2_HUMAN, NM_032683, Q567V2, Q96P34, Q96QA0, Q9BSG4, uc002nid.1, uc002nid.2, uc002nid.3, uc002nid.4, uc002nid.5
UCSC ID: ENST00000599612.3
RefSeq Accession: NM_032683
Protein: Q567V2 (aka M17L2_HUMAN)
CCDS: CCDS42522.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.