Human Gene LSM4 (ENST00000593829.6) from GENCODE V44
Description: Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA. (from RefSeq NM_012321) RefSeq Summary (NM_012321): This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. Gencode Transcript: ENST00000593829.6 Gencode Gene: ENSG00000130520.11 Transcript (Including UTRs) Position: hg38 chr19:18,306,236-18,323,076 Size: 16,841 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr19:18,307,464-18,323,020 Size: 15,557 Coding Exon Count: 5
ID:LSM4_HUMAN DESCRIPTION: RecName: Full=U6 snRNA-associated Sm-like protein LSm4; AltName: Full=Glycine-rich protein; Short=GRP; FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. SUBUNIT: LSm subunits form a heteromer with a doughnut shape. INTERACTION: Q9UK45:LSM7; NbExp=5; IntAct=EBI-372521, EBI-348372; O95777:NAA38; NbExp=4; IntAct=EBI-372521, EBI-347779; SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the snRNP Sm proteins family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y4Z0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
