Human Gene KRTDAP (ENST00000338897.4) from GENCODE V44
  Description: Homo sapiens keratinocyte differentiation associated protein (KRTDAP), transcript variant 1, mRNA. (from RefSeq NM_207392)
RefSeq Summary (NM_207392): This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gencode Transcript: ENST00000338897.4
Gencode Gene: ENSG00000188508.11
Transcript (Including UTRs)
   Position: hg38 chr19:35,487,324-35,490,464 Size: 3,141 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr19:35,487,428-35,490,442 Size: 3,015 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:35,487,324-35,490,464)mRNA (may differ from genome)Protein (99 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KTDAP_HUMAN
DESCRIPTION: RecName: Full=Keratinocyte differentiation-associated protein; Flags: Precursor;
FUNCTION: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.
INDUCTION: Up-regulated in situ in psoriatic skin (at protein level).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2003.81 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 4036.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00220.000 Picture PostScript Text
3' UTR -19.80104-0.190 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on P60985
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process
GO:0030154 cell differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0042599 lamellar body


-  Descriptions from all associated GenBank mRNAs
  AY359007 - Homo sapiens clone DNA57694 KIPV467 (UNQ467) mRNA, complete cds.
AJ293408 - Homo sapiens mRNA differentially expressed in malignant melanoma, clone NN i5.
JD212065 - Sequence 193089 from Patent EP1572962.
BC130501 - Homo sapiens keratinocyte differentiation-associated protein, mRNA (cDNA clone MGC:163373 IMAGE:40146532), complete cds.
AM392851 - Synthetic construct Homo sapiens clone IMAGE:100002912 for hypothetical protein (UNQ467 gene).
AM393477 - Synthetic construct Homo sapiens clone IMAGE:100002910 for hypothetical protein (UNQ467 gene).
HQ258707 - Synthetic construct Homo sapiens clone IMAGE:100072737 keratinocyte differentiation-associated protein (KRTDAP) gene, encodes complete protein.
KJ896189 - Synthetic construct Homo sapiens clone ccsbBroadEn_05583 KRTDAP gene, encodes complete protein.
AM392574 - Synthetic construct Homo sapiens clone IMAGE:100002660 for hypothetical protein (UNQ467 gene).
AM392667 - Synthetic construct Homo sapiens clone IMAGE:100002654 for hypothetical protein (UNQ467 gene).
AM392672 - Synthetic construct Homo sapiens clone IMAGE:100002652 for hypothetical protein (UNQ467 gene).
AM392738 - Synthetic construct Homo sapiens clone IMAGE:100002661 for hypothetical protein (UNQ467 gene).
AM392847 - Synthetic construct Homo sapiens clone IMAGE:100002664 for hypothetical protein (UNQ467 gene).
AM393397 - Synthetic construct Homo sapiens clone IMAGE:100002663 for hypothetical protein (UNQ467 gene).

-  Other Names for This Gene
  Alternate Gene Symbols: A1L4D7, ENST00000338897.1, ENST00000338897.2, ENST00000338897.3, KDAP, KTDAP_HUMAN, NM_207392, P60985, uc002nzh.1, uc002nzh.2, uc002nzh.3, uc002nzh.4, uc002nzh.5, UNQ467/PRO826
UCSC ID: ENST00000338897.4
RefSeq Accession: NM_207392
Protein: P60985 (aka KTDAP_HUMAN)
CCDS: CCDS12462.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.