Human Gene ARHGAP33 (ENST00000314737.9) from GENCODE V44
Description: Homo sapiens Rho GTPase activating protein 33 (ARHGAP33), transcript variant 1, mRNA. (from RefSeq NM_052948) RefSeq Summary (NM_052948): This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]. Gencode Transcript: ENST00000314737.9 Gencode Gene: ENSG00000004777.19 Transcript (Including UTRs) Position: hg38 chr19:35,775,575-35,788,822 Size: 13,248 Total Exon Count: 21 Strand: + Coding Region Position: hg38 chr19:35,775,659-35,788,429 Size: 12,771 Coding Exon Count: 21
ID:RHG33_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 33; AltName: Full=Rho-type GTPase-activating protein 33; AltName: Full=Sorting nexin-26; AltName: Full=Tc10/CDC42 GTPase-activating protein; FUNCTION: May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). SUBUNIT: Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts with NEK6. INTERACTION: P06241:FYN; NbExp=2; IntAct=EBI-1210010, EBI-515315; SIMILARITY: Belongs to the PX domain-containing GAP family. SIMILARITY: Contains 1 PX (phox homology) domain. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAB81198.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14559
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction GO:0009636 response to toxic substance GO:0015031 protein transport GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0061001 regulation of dendritic spine morphogenesis
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