ID:EID2_HUMAN DESCRIPTION: RecName: Full=EP300-interacting inhibitor of differentiation 2; Short=EID-2; AltName: Full=CREBBP/EP300 inhibitor 2; AltName: Full=EID-1-like inhibitor of differentiation 2; FUNCTION: Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. SUBUNIT: Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3. INTERACTION: Q8N140:EID3; NbExp=3; IntAct=EBI-5525894, EBI-744483; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. DOMAIN: The N-terminal portion of EID2 is required for nuclear localization.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q8N6I1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.