Description: Homo sapiens SMG9 nonsense mediated mRNA decay factor (SMG9), mRNA. (from RefSeq NM_019108) RefSeq Summary (NM_019108): This gene encodes a regulatory subunit of the SMG1 complex, which plays a critical role in nonsense-mediated mRNA decay (NMD). Binding of the encoded protein to the SMG1 complex kinase scaffold protein results in the inhibition of its kinase activity. Mutations in this gene cause a multiple congenital anomaly syndrome in human patients, characterized by brain malformation, congenital heart disease and other features. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000270066.11 Gencode Gene: ENSG00000105771.14 Transcript (Including UTRs) Position: hg38 chr19:43,727,983-43,754,962 Size: 26,980 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr19:43,731,596-43,750,741 Size: 19,146 Coding Exon Count: 13
ID:SMG9_HUMAN DESCRIPTION: RecName: Full=Protein SMG9; AltName: Full=Protein smg-9 homolog; FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. SUBUNIT: Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms. INTERACTION: Self; NbExp=3; IntAct=EBI-2872322, EBI-2872322; Q8ND04:SMG8; NbExp=4; IntAct=EBI-2872322, EBI-3903643; PTM: Phosphorylated by SMG1. SIMILARITY: Belongs to the SMG9 family. SEQUENCE CAUTION: Sequence=AAC17932.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0W8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.