Human Gene GRIN2D (ENST00000263269.4) from GENCODE V44
Description: Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), mRNA. (from RefSeq NM_000836) RefSeq Summary (NM_000836): N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]. Gencode Transcript: ENST00000263269.4 Gencode Gene: ENSG00000105464.4 Transcript (Including UTRs) Position: hg38 chr19:48,393,668-48,444,931 Size: 51,264 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr19:48,398,393-48,443,937 Size: 45,545 Coding Exon Count: 12
ID:NMDE4_HUMAN DESCRIPTION: RecName: Full=Glutamate [NMDA] receptor subunit epsilon-4; AltName: Full=EB11; AltName: Full=N-methyl D-aspartate receptor subtype 2D; Short=NMDAR2D; Short=NR2D; Flags: Precursor; FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. SUBUNIT: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01094 - Receptor family ligand binding region PF00060 - Ligand-gated ion channel PF00497 - Bacterial extracellular solute-binding proteins, family 3
ModBase Predicted Comparative 3D Structure on O15399
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.