Human Gene FPR3 (ENST00000339223.5) from GENCODE V44
  Description: Homo sapiens formyl peptide receptor 3 (FPR3), mRNA. (from RefSeq NM_002030)
Gencode Transcript: ENST00000339223.5
Gencode Gene: ENSG00000187474.5
Transcript (Including UTRs)
   Position: hg38 chr19:51,795,157-51,826,190 Size: 31,034 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr19:51,823,749-51,824,810 Size: 1,062 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:51,795,157-51,826,190)mRNA (may differ from genome)Protein (353 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6L5J4_HUMAN
DESCRIPTION: SubName: Full=FML2_HUMAN; SubName: Full=Formyl peptide receptor-like 2; SubName: Full=cDNA FLJ77388, highly similar to Homo sapiens formyl peptide receptor-like 2 (FPRL2), mRNA;
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.95 RPKM in Lung
Total median expression: 63.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.00185-0.184 Picture PostScript Text
3' UTR -377.641380-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000826 - Frt_met_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q6L5J4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004982 N-formyl peptide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK292541 - Homo sapiens cDNA FLJ77388 complete cds, highly similar to Homo sapiens formyl peptide receptor-like 2 (FPRL2), mRNA.
AK123030 - Homo sapiens cDNA FLJ41034 fis, clone HLUNG2000970, highly similar to FMLP-RELATED RECEPTOR II.
BC059388 - Homo sapiens formyl peptide receptor 3, mRNA (cDNA clone MGC:71702 IMAGE:30332008), complete cds.
JD552608 - Sequence 533632 from Patent EP1572962.
JD163114 - Sequence 144138 from Patent EP1572962.
JD429391 - Sequence 410415 from Patent EP1572962.
CU691364 - Synthetic construct Homo sapiens gateway clone IMAGE:100020910 5' read FPRL2 mRNA.
AB463653 - Synthetic construct DNA, clone: pF1KB7154, Homo sapiens FPRL2 gene for formyl peptide receptor-like 2, without stop codon, in Flexi system.
KJ891195 - Synthetic construct Homo sapiens clone ccsbBroadEn_00589 FPR3 gene, encodes complete protein.
BC069070 - Homo sapiens formyl peptide receptor 3, mRNA (cDNA clone MGC:95344 IMAGE:7216883), complete cds.
BC069593 - Homo sapiens formyl peptide receptor 3, mRNA (cDNA clone MGC:97217 IMAGE:7262465), complete cds.
BC069812 - Homo sapiens formyl peptide receptor 3, mRNA (cDNA clone MGC:97206 IMAGE:7262453), complete cds.
M76673 - Human RMLP-related receptor I (RMLP R I) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000339223.1, ENST00000339223.2, ENST00000339223.3, ENST00000339223.4, FPRL2, hCG_91958, NM_002030, Q6L5J4, Q6L5J4_HUMAN, uc002pxt.1, uc002pxt.2, uc002pxt.3
UCSC ID: ENST00000339223.5
RefSeq Accession: NM_002030
Protein: Q6L5J4 CCDS: CCDS12841.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.