Human Gene PEG3 (ENST00000326441.15) from GENCODE V44
Description: Homo sapiens paternally expressed 3 (PEG3), transcript variant 1, mRNA. (from RefSeq NM_006210) RefSeq Summary (NM_006210): In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000326441.15 Gencode Gene: ENSG00000198300.14 Transcript (Including UTRs) Position: hg38 chr19:56,810,082-56,840,726 Size: 30,645 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr19:56,813,675-56,824,655 Size: 10,981 Coding Exon Count: 7
ID:PEG3_HUMAN DESCRIPTION: RecName: Full=Paternally-expressed gene 3 protein; AltName: Full=Zinc finger and SCAN domain-containing protein 24; FUNCTION: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. SUBUNIT: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). TISSUE SPECIFICITY: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 12 C2H2-type zinc fingers. SIMILARITY: Contains 1 SCAN box domain. SEQUENCE CAUTION: Sequence=BAB85588.1; Type=Frameshift; Positions=Several; Sequence=CAI45975.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZU2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0010468 regulation of gene expression GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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