Human Gene ODC1 (ENST00000234111.9) from GENCODE V44
Description: Homo sapiens ornithine decarboxylase 1 (ODC1), transcript variant 1, mRNA. (from RefSeq NM_002539) RefSeq Summary (NM_002539): This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]. Gencode Transcript: ENST00000234111.9 Gencode Gene: ENSG00000115758.14 Transcript (Including UTRs) Position: hg38 chr2:10,439,968-10,448,327 Size: 8,360 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr2:10,440,724-10,445,032 Size: 4,309 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P11926
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001822 kidney development GO:0006521 regulation of cellular amino acid metabolic process GO:0006595 polyamine metabolic process GO:0006596 polyamine biosynthetic process GO:0008284 positive regulation of cell proliferation GO:0009446 putrescine biosynthetic process GO:0009615 response to virus GO:0033387 putrescine biosynthetic process from ornithine GO:0042176 regulation of protein catabolic process
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