Human Gene REG3A (ENST00000409839.7) from GENCODE V44
Description: Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA. (from RefSeq NM_138937) RefSeq Summary (NM_138937): This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]. Gencode Transcript: ENST00000409839.7 Gencode Gene: ENSG00000172016.16 Transcript (Including UTRs) Position: hg38 chr2:79,157,003-79,159,753 Size: 2,751 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr2:79,157,226-79,159,405 Size: 2,180 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q53S56
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.