Human Gene ARID5A (ENST00000357485.8) Description and Page Index
  Description: Homo sapiens AT-rich interaction domain 5A (ARID5A), transcript variant 3, mRNA. (from RefSeq NM_212481)
RefSeq Summary (NM_212481): Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008].
Gencode Transcript: ENST00000357485.8
Gencode Gene: ENSG00000196843.16
Transcript (Including UTRs)
   Position: hg38 chr2:96,536,752-96,552,634 Size: 15,883 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:96,536,827-96,552,313 Size: 15,487 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:96,536,752-96,552,634)mRNA (may differ from genome)Protein (594 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=AT-rich interactive domain-containing protein 5A; Short=ARID domain-containing protein 5A; AltName: Full=Modulator recognition factor 1; Short=MRF-1;
FUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer- dependent gene expressison.
SIMILARITY: Contains 1 ARID domain.
SEQUENCE CAUTION: Sequence=AAA36325.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 68.68 RPKM in Whole Blood
Total median expression: 843.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.6075-0.541 Picture PostScript Text
3' UTR -127.60321-0.398 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure

Pfam Domains:
PF01388 - ARID/BRIGHT DNA binding domain

ModBase Predicted Comparative 3D Structure on Q03989
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0030331 estrogen receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0050681 androgen receptor binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002376 immune system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071391 cellular response to estrogen stimulus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

-  Descriptions from all associated GenBank mRNAs
  LF211736 - JP 2014500723-A/19239: Polycomb-Associated Non-Coding RNAs.
MA447313 - JP 2018138019-A/19239: Polycomb-Associated Non-Coding RNAs.
JD406089 - Sequence 387113 from Patent EP1572962.
AK307768 - Homo sapiens cDNA, FLJ97716.
AK304566 - Homo sapiens cDNA FLJ55425 complete cds, highly similar to Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), transcript variant 1, mRNA.
BX648918 - Homo sapiens mRNA; cDNA DKFZp686F0360 (from clone DKFZp686F0360).
AK300173 - Homo sapiens cDNA FLJ54879 complete cds, highly similar to Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), transcript variant 1, mRNA.
M62324 - Human modulator recognition factor I (MRF-1) mRNA, 3' end.
BC032488 - Homo sapiens AT rich interactive domain 5A (MRF1-like), mRNA (cDNA clone IMAGE:5219759), with apparent retained intron.
BC067301 - Homo sapiens AT rich interactive domain 5A (MRF1-like), mRNA (cDNA clone IMAGE:30409017).
JD219756 - Sequence 200780 from Patent EP1572962.
BC047390 - Homo sapiens AT rich interactive domain 5A (MRF1-like), mRNA (cDNA clone IMAGE:5295251).
BC167773 - Synthetic construct Homo sapiens clone IMAGE:100068163, MGC:195780 AT rich interactive domain 5A (MRF1-like) (ARID5A) mRNA, encodes complete protein.
KJ902164 - Synthetic construct Homo sapiens clone ccsbBroadEn_11558 ARID5A gene, encodes complete protein.
JD465351 - Sequence 446375 from Patent EP1572962.
JD055316 - Sequence 36340 from Patent EP1572962.
JD425523 - Sequence 406547 from Patent EP1572962.
JD042607 - Sequence 23631 from Patent EP1572962.
JD187302 - Sequence 168326 from Patent EP1572962.
JD134116 - Sequence 115140 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARI5A_HUMAN, MRF1, NM_212481, Q03989, Q6NX37, uc002swe.1, uc002swe.2, uc002swe.3, uc002swe.4, uc002swe.5
UCSC ID: uc002swe.5
RefSeq Accession: NM_212481
Protein: Q03989 (aka ARI5A_HUMAN)
CCDS: CCDS33251.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.