Human Gene ARID5A (ENST00000357485.8) Description and Page Index
  Description: Homo sapiens AT-rich interaction domain 5A (ARID5A), transcript variant 3, mRNA. (from RefSeq NM_212481)
RefSeq Summary (NM_212481): Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008].
Gencode Transcript: ENST00000357485.8
Gencode Gene: ENSG00000196843.16
Transcript (Including UTRs)
   Position: hg38 chr2:96,536,752-96,552,634 Size: 15,883 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:96,536,827-96,552,313 Size: 15,487 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:96,536,752-96,552,634)mRNA (may differ from genome)Protein (594 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ARI5A_HUMAN
DESCRIPTION: RecName: Full=AT-rich interactive domain-containing protein 5A; Short=ARID domain-containing protein 5A; AltName: Full=Modulator recognition factor 1; Short=MRF-1;
FUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer- dependent gene expressison.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Contains 1 ARID domain.
SEQUENCE CAUTION: Sequence=AAA36325.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 68.68 RPKM in Whole Blood
Total median expression: 843.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.6075-0.541 Picture PostScript Text
3' UTR -127.60321-0.398 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001606 - ARID/BRIGHT_DNA-bd

Pfam Domains:
PF01388 - ARID/BRIGHT DNA binding domain

ModBase Predicted Comparative 3D Structure on Q03989
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0030331 estrogen receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0050681 androgen receptor binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002376 immune system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071391 cellular response to estrogen stimulus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  LF211736 - JP 2014500723-A/19239: Polycomb-Associated Non-Coding RNAs.
MA447313 - JP 2018138019-A/19239: Polycomb-Associated Non-Coding RNAs.
JD406089 - Sequence 387113 from Patent EP1572962.
AK307768 - Homo sapiens cDNA, FLJ97716.
AK304566 - Homo sapiens cDNA FLJ55425 complete cds, highly similar to Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), transcript variant 1, mRNA.
BX648918 - Homo sapiens mRNA; cDNA DKFZp686F0360 (from clone DKFZp686F0360).
AK300173 - Homo sapiens cDNA FLJ54879 complete cds, highly similar to Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), transcript variant 1, mRNA.
M62324 - Human modulator recognition factor I (MRF-1) mRNA, 3' end.
BC032488 - Homo sapiens AT rich interactive domain 5A (MRF1-like), mRNA (cDNA clone IMAGE:5219759), with apparent retained intron.
BC067301 - Homo sapiens AT rich interactive domain 5A (MRF1-like), mRNA (cDNA clone IMAGE:30409017).
JD219756 - Sequence 200780 from Patent EP1572962.
BC047390 - Homo sapiens AT rich interactive domain 5A (MRF1-like), mRNA (cDNA clone IMAGE:5295251).
BC167773 - Synthetic construct Homo sapiens clone IMAGE:100068163, MGC:195780 AT rich interactive domain 5A (MRF1-like) (ARID5A) mRNA, encodes complete protein.
KJ902164 - Synthetic construct Homo sapiens clone ccsbBroadEn_11558 ARID5A gene, encodes complete protein.
JD465351 - Sequence 446375 from Patent EP1572962.
JD055316 - Sequence 36340 from Patent EP1572962.
JD425523 - Sequence 406547 from Patent EP1572962.
JD042607 - Sequence 23631 from Patent EP1572962.
JD187302 - Sequence 168326 from Patent EP1572962.
JD134116 - Sequence 115140 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARI5A_HUMAN, MRF1, NM_212481, Q03989, Q6NX37, uc002swe.1, uc002swe.2, uc002swe.3, uc002swe.4, uc002swe.5
UCSC ID: uc002swe.5
RefSeq Accession: NM_212481
Protein: Q03989 (aka ARI5A_HUMAN)
CCDS: CCDS33251.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.