Human Gene LRP1B (ENST00000389484.8) from GENCODE V44
Description: Homo sapiens LDL receptor related protein 1B (LRP1B), mRNA. (from RefSeq NM_018557) RefSeq Summary (NM_018557): This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000389484.8 Gencode Gene: ENSG00000168702.18 Transcript (Including UTRs) Position: hg38 chr2:140,231,423-142,131,016 Size: 1,899,594 Total Exon Count: 91 Strand: - Coding Region Position: hg38 chr2:140,233,186-142,130,729 Size: 1,897,544 Coding Exon Count: 91
ID:LRP1B_HUMAN DESCRIPTION: RecName: Full=Low-density lipoprotein receptor-related protein 1B; Short=LRP-1B; AltName: Full=Low-density lipoprotein receptor-related protein-deleted in tumor; Short=LRP-DIT; Flags: Precursor; FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. SUBUNIT: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain. MISCELLANEOUS: The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs. SIMILARITY: Belongs to the LDLR family. SIMILARITY: Contains 14 EGF-like domains. SIMILARITY: Contains 32 LDL-receptor class A domains. SIMILARITY: Contains 36 LDL-receptor class B repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00008 - EGF-like domain PF07645 - Calcium-binding EGF domain PF00057 - Low-density lipoprotein receptor domain class A PF00058 - Low-density lipoprotein receptor repeat class B
ModBase Predicted Comparative 3D Structure on Q9NZR2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
