Human Gene CHRNA1 (ENST00000348749.9) from GENCODE V44
Description: Homo sapiens cholinergic receptor nicotinic alpha 1 subunit (CHRNA1), transcript variant 2, mRNA. (from RefSeq NM_000079) RefSeq Summary (NM_000079): The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]. Gencode Transcript: ENST00000348749.9 Gencode Gene: ENSG00000138435.16 Transcript (Including UTRs) Position: hg38 chr2:174,747,592-174,764,472 Size: 16,881 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr2:174,748,124-174,764,394 Size: 16,271 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q53SH4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0007165 signal transduction GO:0034220 ion transmembrane transport GO:0060078 regulation of postsynaptic membrane potential GO:0060079 excitatory postsynaptic potential
BC043196 - Homo sapiens cholinergic receptor, nicotinic, alpha 1 (muscle), mRNA (cDNA clone IMAGE:5288924), with apparent retained intron. AK299445 - Homo sapiens cDNA FLJ58615 complete cds, highly similar to Acetylcholine receptor protein subunit alpha precursor. S77094 - nicotinic acetylcholine receptor alpha subunit|AChR alpha subunit [human, thymic carcinoma, myasthenia gravis-associated thymoma patient 1494/88, mRNA Partial, 1676 nt]. Y00762 - Human mRNA for muscle acetylcholine receptor alpha-subunit. JD500866 - Sequence 481890 from Patent EP1572962. JD244924 - Sequence 225948 from Patent EP1572962. AK291338 - Homo sapiens cDNA FLJ77888 complete cds, highly similar to Human mRNA for muscle acetylcholine receptor alpha-subunit. JD411470 - Sequence 392494 from Patent EP1572962. JD419373 - Sequence 400397 from Patent EP1572962. JD503043 - Sequence 484067 from Patent EP1572962. AK315312 - Homo sapiens cDNA, FLJ96344, Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 1(muscle) (CHRNA1), mRNA. BC006314 - Homo sapiens cholinergic receptor, nicotinic, alpha 1 (muscle), mRNA (cDNA clone IMAGE:4124038), with apparent retained intron. KJ901339 - Synthetic construct Homo sapiens clone ccsbBroadEn_10733 CHRNA1 gene, encodes complete protein. KR710048 - Synthetic construct Homo sapiens clone CCSBHm_00009235 CHRNA1 (CHRNA1) mRNA, encodes complete protein. KR710049 - Synthetic construct Homo sapiens clone CCSBHm_00009237 CHRNA1 (CHRNA1) mRNA, encodes complete protein. KR710050 - Synthetic construct Homo sapiens clone CCSBHm_00009238 CHRNA1 (CHRNA1) mRNA, encodes complete protein. KR710051 - Synthetic construct Homo sapiens clone CCSBHm_00009239 CHRNA1 (CHRNA1) mRNA, encodes complete protein. DQ323657 - Homo sapiens clone 66 muscle nicotinic acetylcholine receptor mRNA, partial cds. DQ323658 - Homo sapiens clone 67 muscle nicotinic acetylcholine receptor mRNA, partial cds. JD050179 - Sequence 31203 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction
BioCarta from NCI Cancer Genome Anatomy Project h_botulinPathway - Blockade of Neurotransmitter Relase by Botulinum Toxin h_agrPathway - Agrin in Postsynaptic Differentiation h_no1Pathway - Actions of Nitric Oxide in the Heart