Human Gene PTH2R (ENST00000272847.7) from GENCODE V44
Description: Homo sapiens parathyroid hormone 2 receptor (PTH2R), transcript variant 1, mRNA. (from RefSeq NM_005048) RefSeq Summary (NM_005048): The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000272847.7 Gencode Gene: ENSG00000144407.10 Transcript (Including UTRs) Position: hg38 chr2:208,406,792-208,494,506 Size: 87,715 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr2:208,407,044-208,493,659 Size: 86,616 Coding Exon Count: 13
ID:PTH2R_HUMAN DESCRIPTION: RecName: Full=Parathyroid hormone 2 receptor; Short=PTH2 receptor; Flags: Precursor; FUNCTION: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). SUBUNIT: Binds to TIPF39/TIP39. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed abundantly in brain and pancreas. Also expressed in the testis. SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49190
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.