Human Gene PECR (ENST00000265322.8) from GENCODE V44
  Description: Homo sapiens peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA. (from RefSeq NM_018441)
Gencode Transcript: ENST00000265322.8
Gencode Gene: ENSG00000115425.14
Transcript (Including UTRs)
   Position: hg38 chr2:216,038,388-216,081,809 Size: 43,422 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr2:216,039,275-216,081,741 Size: 42,467 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:216,038,388-216,081,809)mRNA (may differ from genome)Protein (303 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PECR_HUMAN
DESCRIPTION: RecName: Full=Peroxisomal trans-2-enoyl-CoA reductase; Short=TERP; EC=1.3.1.38; AltName: Full=2,4-dienoyl-CoA reductase-related protein; Short=DCR-RP; AltName: Full=HPDHase; AltName: Full=pVI-ARL;
FUNCTION: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.
CATALYTIC ACTIVITY: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
PATHWAY: Lipid metabolism; fatty acid biosynthesis.
SUBUNIT: Interacts with PEX5, probably required to target it into peroxisomes.
SUBCELLULAR LOCATION: Peroxisome.
INDUCTION: Not induced by IR.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SEQUENCE CAUTION: Sequence=AAF69798.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.97 RPKM in Liver
Total median expression: 133.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.9068-0.278 Picture PostScript Text
3' UTR -208.60887-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YXM - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BY49
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0016491 oxidoreductase activity
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity

Biological Process:
GO:0001561 fatty acid alpha-oxidation
GO:0006625 protein targeting to peroxisome
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0033306 phytol metabolic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK296208 - Homo sapiens cDNA FLJ55082 complete cds, highly similar to Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38).
AF119841 - Homo sapiens PRO1004 mRNA, complete cds.
LF383617 - JP 2014500723-A/191120: Polycomb-Associated Non-Coding RNAs.
MA619194 - JP 2018138019-A/191120: Polycomb-Associated Non-Coding RNAs.
JD299358 - Sequence 280382 from Patent EP1572962.
AF232009 - Homo sapiens peroxisomal trans 2-enoyl CoA reductase mRNA, complete cds.
BC002529 - Homo sapiens peroxisomal trans-2-enoyl-CoA reductase, mRNA (cDNA clone MGC:2578 IMAGE:3139219), complete cds.
JD375166 - Sequence 356190 from Patent EP1572962.
JD536036 - Sequence 517060 from Patent EP1572962.
JD156453 - Sequence 137477 from Patent EP1572962.
JD105973 - Sequence 86997 from Patent EP1572962.
JD517754 - Sequence 498778 from Patent EP1572962.
JD230985 - Sequence 212009 from Patent EP1572962.
JD144180 - Sequence 125204 from Patent EP1572962.
JD257762 - Sequence 238786 from Patent EP1572962.
JD352111 - Sequence 333135 from Patent EP1572962.
JD238487 - Sequence 219511 from Patent EP1572962.
JD243311 - Sequence 224335 from Patent EP1572962.
JD097698 - Sequence 78722 from Patent EP1572962.
JD136273 - Sequence 117297 from Patent EP1572962.
JD194910 - Sequence 175934 from Patent EP1572962.
JD136272 - Sequence 117296 from Patent EP1572962.
JD194909 - Sequence 175933 from Patent EP1572962.
JD231880 - Sequence 212904 from Patent EP1572962.
JD315863 - Sequence 296887 from Patent EP1572962.
JD511606 - Sequence 492630 from Patent EP1572962.
JD286821 - Sequence 267845 from Patent EP1572962.
JD319923 - Sequence 300947 from Patent EP1572962.
JD319922 - Sequence 300946 from Patent EP1572962.
JD533726 - Sequence 514750 from Patent EP1572962.
JD291748 - Sequence 272772 from Patent EP1572962.
JD370253 - Sequence 351277 from Patent EP1572962.
AJ250303 - Homo sapiens mRNA for peroxisomal 2-enoyl-CoA reductase.
AF212234 - Homo sapiens HPDHase mRNA, complete cds.
JD223559 - Sequence 204583 from Patent EP1572962.
EU832649 - Synthetic construct Homo sapiens clone HAIB:100067678; DKFZo008E1131 peroxisomal trans-2-enoyl-CoA reductase protein (PECR) gene, encodes complete protein.
KJ899200 - Synthetic construct Homo sapiens clone ccsbBroadEn_08594 PECR gene, encodes complete protein.
AK315795 - Homo sapiens cDNA, FLJ96915, Homo sapiens peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA.
EU832727 - Synthetic construct Homo sapiens clone HAIB:100067756; DKFZo004E1132 peroxisomal trans-2-enoyl-CoA reductase protein (PECR) gene, encodes complete protein.
AB464010 - Synthetic construct DNA, clone: pF1KB6394, Homo sapiens PECR gene for peroxisomal trans-2-enoyl-CoA reductase, without stop codon, in Flexi system.
CR457145 - Homo sapiens full open reading frame cDNA clone RZPDo834A038D for gene PECR, peroxisomal trans-2-enoyl-CoA reductase; complete cds, incl. stopcodon.
LF318452 - JP 2014500723-A/125955: Polycomb-Associated Non-Coding RNAs.
MA554029 - JP 2018138019-A/125955: Polycomb-Associated Non-Coding RNAs.
LF318453 - JP 2014500723-A/125956: Polycomb-Associated Non-Coding RNAs.
MA554030 - JP 2018138019-A/125956: Polycomb-Associated Non-Coding RNAs.
BC011871 - Homo sapiens mRNA similar to x 010 protein (cDNA clone IMAGE:3009963).
LF318457 - JP 2014500723-A/125960: Polycomb-Associated Non-Coding RNAs.
MA554034 - JP 2018138019-A/125960: Polycomb-Associated Non-Coding RNAs.
LF318459 - JP 2014500723-A/125962: Polycomb-Associated Non-Coding RNAs.
MA554036 - JP 2018138019-A/125962: Polycomb-Associated Non-Coding RNAs.
JD054760 - Sequence 35784 from Patent EP1572962.
JD193995 - Sequence 175019 from Patent EP1572962.
JD399913 - Sequence 380937 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa01040 - Biosynthesis of unsaturated fatty acids
hsa04146 - Peroxisome

BioCyc Knowledge Library
PWY66-389 - phytol degradation

Reactome (by CSHL, EBI, and GO)

Protein Q9BY49 (Reactome details) participates in the following event(s):

R-HSA-9033233 PEX5S,L binds cargo proteins containing PTS1
R-HSA-6809810 PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA
R-HSA-9033236 PEX5S,L:Cargo binds PEX13:PEX14 of PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Complex)
R-HSA-9033241 Peroxisomal protein import
R-HSA-389599 Alpha-oxidation of phytanate
R-HSA-392499 Metabolism of proteins
R-HSA-390918 Peroxisomal lipid metabolism
R-HSA-8978868 Fatty acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2RE42, ENST00000265322.1, ENST00000265322.2, ENST00000265322.3, ENST00000265322.4, ENST00000265322.5, ENST00000265322.6, ENST00000265322.7, NM_018441, PECR_HUMAN, PRO1004, Q53TC4, Q6IAK9, Q9BY49, Q9NRD4, Q9NY60, Q9P1A4, uc002vft.1, uc002vft.2, uc002vft.3, uc002vft.4, uc002vft.5
UCSC ID: ENST00000265322.8
RefSeq Accession: NM_018441
Protein: Q9BY49 (aka PECR_HUMAN)
CCDS: CCDS33375.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.