Human Gene PECR (ENST00000265322.8) from GENCODE V44
Description: Homo sapiens peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA. (from RefSeq NM_018441)
Gencode Transcript: ENST00000265322.8
Gencode Gene: ENSG00000115425.14
Transcript (Including UTRs)
Position: hg38 chr2:216,038,388-216,081,809 Size: 43,422 Total Exon Count: 8 Strand: -
Coding Region
Position: hg38 chr2:216,039,275-216,081,741 Size: 42,467 Coding Exon Count: 8
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PECR_HUMAN
DESCRIPTION: RecName: Full=Peroxisomal trans-2-enoyl-CoA reductase; Short=TERP; EC=1.3.1.38; AltName: Full=2,4-dienoyl-CoA reductase-related protein; Short=DCR-RP; AltName: Full=HPDHase; AltName: Full=pVI-ARL;
FUNCTION: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.CATALYTIC ACTIVITY: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.PATHWAY: Lipid metabolism; fatty acid biosynthesis.SUBUNIT: Interacts with PEX5, probably required to target it into peroxisomes.SUBCELLULAR LOCATION: Peroxisome.INDUCTION: Not induced by IR.SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.SEQUENCE CAUTION: Sequence=AAF69798.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9BY49
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK296208 - Homo sapiens cDNA FLJ55082 complete cds, highly similar to Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38).AF119841 - Homo sapiens PRO1004 mRNA, complete cds.LF383617 - JP 2014500723-A/191120: Polycomb-Associated Non-Coding RNAs.MA619194 - JP 2018138019-A/191120: Polycomb-Associated Non-Coding RNAs.JD299358 - Sequence 280382 from Patent EP1572962.AF232009 - Homo sapiens peroxisomal trans 2-enoyl CoA reductase mRNA, complete cds.BC002529 - Homo sapiens peroxisomal trans-2-enoyl-CoA reductase, mRNA (cDNA clone MGC:2578 IMAGE:3139219), complete cds.JD375166 - Sequence 356190 from Patent EP1572962.JD536036 - Sequence 517060 from Patent EP1572962.JD156453 - Sequence 137477 from Patent EP1572962.JD105973 - Sequence 86997 from Patent EP1572962.JD517754 - Sequence 498778 from Patent EP1572962.JD230985 - Sequence 212009 from Patent EP1572962.JD144180 - Sequence 125204 from Patent EP1572962.JD257762 - Sequence 238786 from Patent EP1572962.JD352111 - Sequence 333135 from Patent EP1572962.JD238487 - Sequence 219511 from Patent EP1572962.JD243311 - Sequence 224335 from Patent EP1572962.JD097698 - Sequence 78722 from Patent EP1572962.JD136273 - Sequence 117297 from Patent EP1572962.JD194910 - Sequence 175934 from Patent EP1572962.JD136272 - Sequence 117296 from Patent EP1572962.JD194909 - Sequence 175933 from Patent EP1572962.JD231880 - Sequence 212904 from Patent EP1572962.JD315863 - Sequence 296887 from Patent EP1572962.JD511606 - Sequence 492630 from Patent EP1572962.JD286821 - Sequence 267845 from Patent EP1572962.JD319923 - Sequence 300947 from Patent EP1572962.JD319922 - Sequence 300946 from Patent EP1572962.JD533726 - Sequence 514750 from Patent EP1572962.JD291748 - Sequence 272772 from Patent EP1572962.JD370253 - Sequence 351277 from Patent EP1572962.AJ250303 - Homo sapiens mRNA for peroxisomal 2-enoyl-CoA reductase.AF212234 - Homo sapiens HPDHase mRNA, complete cds.JD223559 - Sequence 204583 from Patent EP1572962.EU832649 - Synthetic construct Homo sapiens clone HAIB:100067678; DKFZo008E1131 peroxisomal trans-2-enoyl-CoA reductase protein (PECR) gene, encodes complete protein.KJ899200 - Synthetic construct Homo sapiens clone ccsbBroadEn_08594 PECR gene, encodes complete protein.AK315795 - Homo sapiens cDNA, FLJ96915, Homo sapiens peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA.EU832727 - Synthetic construct Homo sapiens clone HAIB:100067756; DKFZo004E1132 peroxisomal trans-2-enoyl-CoA reductase protein (PECR) gene, encodes complete protein.AB464010 - Synthetic construct DNA, clone: pF1KB6394, Homo sapiens PECR gene for peroxisomal trans-2-enoyl-CoA reductase, without stop codon, in Flexi system.CR457145 - Homo sapiens full open reading frame cDNA clone RZPDo834A038D for gene PECR, peroxisomal trans-2-enoyl-CoA reductase; complete cds, incl. stopcodon.LF318452 - JP 2014500723-A/125955: Polycomb-Associated Non-Coding RNAs.MA554029 - JP 2018138019-A/125955: Polycomb-Associated Non-Coding RNAs.LF318453 - JP 2014500723-A/125956: Polycomb-Associated Non-Coding RNAs.MA554030 - JP 2018138019-A/125956: Polycomb-Associated Non-Coding RNAs.BC011871 - Homo sapiens mRNA similar to x 010 protein (cDNA clone IMAGE:3009963).LF318457 - JP 2014500723-A/125960: Polycomb-Associated Non-Coding RNAs.MA554034 - JP 2018138019-A/125960: Polycomb-Associated Non-Coding RNAs.LF318459 - JP 2014500723-A/125962: Polycomb-Associated Non-Coding RNAs.MA554036 - JP 2018138019-A/125962: Polycomb-Associated Non-Coding RNAs.JD054760 - Sequence 35784 from Patent EP1572962.JD193995 - Sequence 175019 from Patent EP1572962.JD399913 - Sequence 380937 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B2RE42, ENST00000265322.1, ENST00000265322.2, ENST00000265322.3, ENST00000265322.4, ENST00000265322.5, ENST00000265322.6, ENST00000265322.7, NM_018441, PECR_HUMAN, PRO1004, Q53TC4, Q6IAK9, Q9BY49, Q9NRD4, Q9NY60, Q9P1A4, uc002vft.1, uc002vft.2, uc002vft.3, uc002vft.4, uc002vft.5UCSC ID: ENST00000265322.8RefSeq Accession: NM_018441
Protein: Q9BY49
(aka PECR_HUMAN)
CCDS: CCDS33375.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.