Human Gene TNS1 (ENST00000171887.8) from GENCODE V44
Description: Homo sapiens tensin 1 (TNS1), transcript variant 1, mRNA. (from RefSeq NM_022648) RefSeq Summary (NM_022648): The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. Gencode Transcript: ENST00000171887.8 Gencode Gene: ENSG00000079308.21 Transcript (Including UTRs) Position: hg38 chr2:217,799,789-217,944,128 Size: 144,340 Total Exon Count: 33 Strand: - Coding Region Position: hg38 chr2:217,804,459-217,897,965 Size: 93,507 Coding Exon Count: 28
ID:TENS1_HUMAN DESCRIPTION: RecName: Full=Tensin-1; FUNCTION: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. SUBUNIT: Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8. SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Ubiquitous. PTM: Rapidly cleaved by calpain II. SIMILARITY: Contains 1 C2 tensin-type domain. SIMILARITY: Contains 1 phosphatase tensin-type domain. SIMILARITY: Contains 1 SH2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08416 - Phosphotyrosine-binding domain PF10409 - C2 domain of PTEN tumour-suppressor protein PF00017 - SH2 domain
ModBase Predicted Comparative 3D Structure on Q9HBL0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
