Human Gene CXCR1 (ENST00000295683.3) from GENCODE V44
Description: Homo sapiens C-X-C motif chemokine receptor 1 (CXCR1), mRNA. (from RefSeq NM_000634) RefSeq Summary (NM_000634): The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000295683.3 Gencode Gene: ENSG00000163464.8 Transcript (Including UTRs) Position: hg38 chr2:218,162,841-218,166,962 Size: 4,122 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr2:218,164,159-218,165,211 Size: 1,053 Coding Exon Count: 1
ID:CXCR1_HUMAN DESCRIPTION: RecName: Full=C-X-C chemokine receptor type 1; Short=CXC-R1; Short=CXCR-1; AltName: Full=CDw128a; AltName: Full=High affinity interleukin-8 receptor A; Short=IL-8R A; AltName: Full=IL-8 receptor type 1; AltName: CD_antigen=CD181; FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CXC_chemokine_receptors"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il8ra/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25024
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
