Human Gene TRPM8 (ENST00000324695.9) from GENCODE V44
  Description: Homo sapiens transient receptor potential cation channel subfamily M member 8 (TRPM8), mRNA. (from RefSeq NM_024080)
Gencode Transcript: ENST00000324695.9
Gencode Gene: ENSG00000144481.17
Transcript (Including UTRs)
   Position: hg38 chr2:233,917,373-234,019,522 Size: 102,150 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg38 chr2:233,926,538-234,014,612 Size: 88,075 Coding Exon Count: 24 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:233,917,373-234,019,522)mRNA (may differ from genome)Protein (1104 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TRPM8
Diseases sorted by gene-association score: prostate cancer (7), dentin sensitivity (3), migraine with or without aura 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D008610 Menthol
  • C490483 icilin
  • D002118 Calcium
  • C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide
  • C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
  • C009505 4,4'-diaminodiphenylmethane
  • C068314 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one
  • D000082 Acetaminophen
  • D000096 Acetone
  • D000643 Ammonium Chloride
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.98 RPKM in Prostate
Total median expression: 12.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.1065-0.232 Picture PostScript Text
3' UTR -537.502266-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  KJ903143 - Synthetic construct Homo sapiens clone ccsbBroadEn_12537 TRPM8 gene, encodes complete protein.
KJ903144 - Synthetic construct Homo sapiens clone ccsbBroadEn_12538 TRPM8 gene, encodes complete protein.
KT341010 - Homo sapiens transient receptor melastatin 8 variant 11 (TRPM8) mRNA, complete cds.
KT341009 - Homo sapiens transient receptor melastatin 8 variant 10 (TRPM8) mRNA, complete cds.
KC692993 - Homo sapiens transient receptor melastatin 8 (TRPM8) mRNA, complete cds.
AY090109 - Homo sapiens transient receptor potential cation channel protein (TRPM8) mRNA, complete cds.
BC143819 - Homo sapiens cDNA clone IMAGE:9052334.
BC126342 - Homo sapiens transient receptor potential cation channel, subfamily M, member 8, mRNA (cDNA clone MGC:161620 IMAGE:8992058), complete cds.
AY328400 - Homo sapiens transient receptor potential subfamily M member 8 variant (TRPM8) mRNA, complete cds.
DQ139309 - Homo sapiens transient receptor potential subfamily M member 8 (TRPM8) mRNA, complete cds.
AB061779 - Homo sapiens mRNA for LTRPC6, complete cds.
KT341012 - Homo sapiens transient receptor melastatin 8 variant 13 (TRPM8) mRNA, complete cds.
KT341011 - Homo sapiens transient receptor melastatin 8 variant 12 (TRPM8) mRNA, complete cds.
KT341013 - Homo sapiens transient receptor melastatin 8 variant 14 (TRPM8) mRNA, complete cds.
KT341014 - Homo sapiens transient receptor melastatin 8 variant 15 (TRPM8) mRNA, complete cds.
KT341019 - Homo sapiens transient receptor melastatin 8 variant 20 (TRPM8) mRNA, complete cds.
KT341015 - Homo sapiens transient receptor melastatin 8 variant 16 (TRPM8) mRNA, complete cds.
KT341016 - Homo sapiens transient receptor melastatin 8 variant 17 (TRPM8) mRNA, complete cds.
KT341017 - Homo sapiens transient receptor melastatin 8 variant 18 (TRPM8) mRNA, complete cds.
KT341018 - Homo sapiens transient receptor melastatin 8 variant 19 (TRPM8) mRNA, complete cds.
KT341020 - Homo sapiens transient receptor melastatin 8 variant 21 (TRPM8) mRNA, complete cds.
HQ258493 - Synthetic construct Homo sapiens clone IMAGE:100072922 Unknown protein gene, encodes complete protein.
KT341021 - Homo sapiens transient receptor melastatin 8 variant 22 (TRPM8) mRNA, complete cds.
KT341022 - Homo sapiens transient receptor melastatin 8 variant 23 (TRPM8) mRNA, complete cds.
FJ895300 - Homo sapiens TRPM8 (TRPM8) mRNA, partial cds.
KT341002 - Homo sapiens transient receptor melastatin 8 variant 3 (TRPM8) mRNA, complete cds.
JD042318 - Sequence 23342 from Patent EP1572962.
KT341003 - Homo sapiens transient receptor melastatin 8 variant 4 (TRPM8) mRNA, complete cds.
KT341004 - Homo sapiens transient receptor melastatin 8 variant 5 (TRPM8) mRNA, complete cds.
KT341005 - Homo sapiens transient receptor melastatin 8 variant 6 (TRPM8) mRNA, complete cds.
BC001135 - Homo sapiens transient receptor potential cation channel, subfamily M, member 8, mRNA (cDNA clone IMAGE:2967357), complete cds.
AY532375 - Homo sapiens short transient receptor potential subfamily M member 8, variant alpha (TRPM8) mRNA, complete cds, alternatively spliced.
AY532376 - Homo sapiens short transient receptor potential subfamily M member 8, variant beta (TRPM8) mRNA, complete cds, alternatively spliced.
KT341006 - Homo sapiens nonfunctional transient receptor melastatin 8 variant 7 (TRPM8) mRNA, complete sequence.
KT341007 - Homo sapiens transient receptor melastatin 8 variant 8 (TRPM8) mRNA, complete cds.
CU674574 - Synthetic construct Homo sapiens gateway clone IMAGE:100018011 5' read TRPM8 mRNA.
KT341008 - Homo sapiens nonfunctional transient receptor melastatin 8 variant 9 (TRPM8) mRNA, complete sequence.
KC692994 - Homo sapiens TRPM8 isoform, 40kDa channel protein (TRPM8) mRNA, complete cds.
KC692995 - Homo sapiens TRPM8 isoform 51kDa channel protein (TRPM8) mRNA, complete cds.
KT341023 - Homo sapiens transient receptor melastatin 8 variant 24 (TRPM8) mRNA, complete cds.
KT341026 - Homo sapiens nonfunctional transient receptor melastatin 8 variant 27 (TRPM8) mRNA, complete sequence.
KT341024 - Homo sapiens transient receptor melastatin 8 variant 25 (TRPM8) mRNA, complete cds.
KT341025 - Homo sapiens transient receptor melastatin 8 variant 26 (TRPM8) mRNA, complete cds.
KT341027 - Homo sapiens transient receptor melastatin 8 variant 28 (TRPM8) mRNA, complete cds.
KT341028 - Homo sapiens transient receptor melastatin 8 variant 29 isoform 35kDa (TRPM8) mRNA, complete cds.
KT341029 - Homo sapiens transient receptor melastatin 8 variant 29 isoform 27kDa (TRPM8) mRNA, complete cds.
KT341030 - Homo sapiens transient receptor melastatin 8 variant 30 (TRPM8) mRNA, complete cds.
KT341031 - Homo sapiens transient receptor melastatin 8 variant 31 (TRPM8) mRNA, complete cds.
KT341032 - Homo sapiens transient receptor melastatin 8 variant 32 isoform 35kDa (TRPM8) mRNA, complete cds.
KT341033 - Homo sapiens transient receptor melastatin 8 variant 32 isoform 27kDa (TRPM8) mRNA, complete cds.
KT341034 - Homo sapiens transient receptor melastatin 8 variant 33 (TRPM8) mRNA, complete cds.
KT341035 - Homo sapiens transient receptor melastatin 8 variant 34 (TRPM8) mRNA, complete cds.
AK303811 - Homo sapiens cDNA FLJ56776 complete cds, highly similar to Transient receptor potential cation channel subfamily M member 8.
BC033137 - Homo sapiens, Similar to transient receptor potential cation channel, subfamily M, member 8, clone IMAGE:3638172, mRNA.
JD510427 - Sequence 491451 from Patent EP1572962.
JD442227 - Sequence 423251 from Patent EP1572962.
JD248119 - Sequence 229143 from Patent EP1572962.
JD146543 - Sequence 127567 from Patent EP1572962.
JD245211 - Sequence 226235 from Patent EP1572962.
JD412575 - Sequence 393599 from Patent EP1572962.
JD354884 - Sequence 335908 from Patent EP1572962.
JD350494 - Sequence 331518 from Patent EP1572962.
JD245028 - Sequence 226052 from Patent EP1572962.
JD333661 - Sequence 314685 from Patent EP1572962.
JD285958 - Sequence 266982 from Patent EP1572962.
JD478919 - Sequence 459943 from Patent EP1572962.
JD474077 - Sequence 455101 from Patent EP1572962.
JD551601 - Sequence 532625 from Patent EP1572962.
JD503258 - Sequence 484282 from Patent EP1572962.
JD299665 - Sequence 280689 from Patent EP1572962.
JD158783 - Sequence 139807 from Patent EP1572962.
JD275645 - Sequence 256669 from Patent EP1572962.
JD208628 - Sequence 189652 from Patent EP1572962.
JD378622 - Sequence 359646 from Patent EP1572962.
JD479527 - Sequence 460551 from Patent EP1572962.
JD183824 - Sequence 164848 from Patent EP1572962.
JD091991 - Sequence 73015 from Patent EP1572962.
JD292377 - Sequence 273401 from Patent EP1572962.
JD534407 - Sequence 515431 from Patent EP1572962.
JD451484 - Sequence 432508 from Patent EP1572962.
JD364510 - Sequence 345534 from Patent EP1572962.
JD318867 - Sequence 299891 from Patent EP1572962.
JD366189 - Sequence 347213 from Patent EP1572962.
JD517171 - Sequence 498195 from Patent EP1572962.
JD168689 - Sequence 149713 from Patent EP1572962.
JD039713 - Sequence 20737 from Patent EP1572962.
JD327036 - Sequence 308060 from Patent EP1572962.
JD547542 - Sequence 528566 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000324695.1, ENST00000324695.2, ENST00000324695.3, ENST00000324695.4, ENST00000324695.5, ENST00000324695.6, ENST00000324695.7, ENST00000324695.8, NM_024080, uc002vvh.1, uc002vvh.2, uc002vvh.3, uc002vvh.4, W8DTH1
UCSC ID: ENST00000324695.9
RefSeq Accession: NM_024080
CCDS: CCDS33407.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.