Human Gene GFRA4 (ENST00000290417.7) from GENCODE V44
Description: Homo sapiens GDNF family receptor alpha 4 (GFRA4), transcript variant 1, mRNA. (from RefSeq NM_022139) RefSeq Summary (NM_022139): The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000290417.7 Gencode Gene: ENSG00000125861.16 Transcript (Including UTRs) Position: hg38 chr20:3,659,248-3,663,399 Size: 4,152 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr20:3,659,909-3,663,399 Size: 3,491 Coding Exon Count: 6
ID:GFRA4_HUMAN DESCRIPTION: RecName: Full=GDNF family receptor alpha-4; Short=GDNF receptor alpha-4; Short=GDNFR-alpha-4; Short=GFR-alpha-4; AltName: Full=Persephin receptor; Flags: Precursor; FUNCTION: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. SUBCELLULAR LOCATION: Isoform GFRalpha4a: Cell membrane; Lipid- anchor, GPI-anchor. SUBCELLULAR LOCATION: Isoform GFRalpha4b: Cell membrane; Lipid- anchor, GPI-anchor. SUBCELLULAR LOCATION: Isoform GFRalpha4c: Secreted. TISSUE SPECIFICITY: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. SIMILARITY: Belongs to the GDNFR family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZZ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.