Human Gene SNX5 (ENST00000377768.7) from GENCODE V44
Description: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. (from UniProt Q9Y5X3) RefSeq Summary (NM_152227): This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000377768.7 Gencode Gene: ENSG00000089006.17 Transcript (Including UTRs) Position: hg38 chr20:17,941,597-17,968,980 Size: 27,384 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr20:17,942,357-17,968,425 Size: 26,069 Coding Exon Count: 13
ID:SNX5_HUMAN DESCRIPTION: RecName: Full=Sorting nexin-5; FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. SUBUNIT: Interacts with SNX1; this promotes location at the endosome membrane. SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation. DOMAIN: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (By similarity). SIMILARITY: Belongs to the sorting nexin family. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 PX (phox homology) domain. CAUTION: The selectivity for particular phosphatidylinositol lipids is under debate. According to one report (PubMed:19553671), the rat protein binds exclusively to phosphatidylinositol 4,5- bisphosphate, while the human protein has been reported (PubMed:15561769) to bind to phosphatidylinositol 3,4-bisphosphate and also to phosphatidylinositol 3-phosphate.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5X3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006897 endocytosis GO:0006907 pinocytosis GO:0007174 epidermal growth factor catabolic process GO:0015031 protein transport GO:0016050 vesicle organization GO:0016241 regulation of macroautophagy GO:0035815 positive regulation of renal sodium excretion GO:0042147 retrograde transport, endosome to Golgi GO:0045776 negative regulation of blood pressure
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