ID:NAA20_HUMAN DESCRIPTION: RecName: Full=N-alpha-acetyltransferase 20; EC=2.3.1.88; AltName: Full=Methionine N-acetyltransferase; AltName: Full=N-acetyltransferase 5; AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAA20; AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAT5; Short=NatB complex subunit NAT5; AltName: Full=NatB catalytic subunit; FUNCTION: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. CATALYTIC ACTIVITY: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA. SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. SIMILARITY: Belongs to the acetyltransferase family. ARD1 subfamily. SIMILARITY: Contains 1 N-acetyltransferase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00583 - Acetyltransferase (GNAT) family
ModBase Predicted Comparative 3D Structure on P61599
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
