Human Gene SLC32A1 (ENST00000217420.2) from GENCODE V44
Description: Homo sapiens solute carrier family 32 member 1 (SLC32A1), mRNA. (from RefSeq NM_080552) RefSeq Summary (NM_080552): The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000217420.2 Gencode Gene: ENSG00000101438.4 Transcript (Including UTRs) Position: hg38 chr20:38,724,486-38,729,372 Size: 4,887 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr20:38,724,725-38,728,639 Size: 3,915 Coding Exon Count: 2
ID:VIAAT_HUMAN DESCRIPTION: RecName: Full=Vesicular inhibitory amino acid transporter; AltName: Full=GABA and glycine transporter; AltName: Full=Solute carrier family 32 member 1; AltName: Full=Vesicular GABA transporter; Short=hVIAAT; FUNCTION: Involved in the uptake of GABA and glycine into the synaptic vesicles. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Retina. Expressed throughout the horizontal cells or more specifically at the terminals. SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family. SEQUENCE CAUTION: Sequence=AAH36458.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01490 - Transmembrane amino acid transporter protein
ModBase Predicted Comparative 3D Structure on Q9H598
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.