Human Gene KCNS1 (ENST00000306117.5) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel modifier subfamily S member 1 (KCNS1), transcript variant 1, mRNA. (from RefSeq NM_002251) RefSeq Summary (NM_002251): Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000306117.5 Gencode Gene: ENSG00000124134.9 Transcript (Including UTRs) Position: hg38 chr20:45,092,310-45,101,112 Size: 8,803 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr20:45,094,870-45,099,236 Size: 4,367 Coding Exon Count: 3
ID:KCNS1_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily S member 1; AltName: Full=Delayed-rectifier K(+) channel alpha subunit 1; AltName: Full=Voltage-gated potassium channel subunit Kv9.1; FUNCTION: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity). SUBUNIT: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. TISSUE SPECIFICITY: Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. SIMILARITY: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF02214 - BTB/POZ domain
ModBase Predicted Comparative 3D Structure on Q96KK3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0051260 protein homooligomerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport GO:1902259 regulation of delayed rectifier potassium channel activity
Cellular Component: GO:0005886 plasma membrane GO:0008076 voltage-gated potassium channel complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0048471 perinuclear region of cytoplasm
Descriptions from all associated GenBank mRNAs
AF043473 - Homo sapiens delayed-rectifier K+ channel alpha subunit (KCNS1) mRNA, complete cds. JD038643 - Sequence 19667 from Patent EP1572962. JD050752 - Sequence 31776 from Patent EP1572962. JD338442 - Sequence 319466 from Patent EP1572962. JD210011 - Sequence 191035 from Patent EP1572962. JD376555 - Sequence 357579 from Patent EP1572962. JD476978 - Sequence 458002 from Patent EP1572962. JD046077 - Sequence 27101 from Patent EP1572962. JD548815 - Sequence 529839 from Patent EP1572962. JD503723 - Sequence 484747 from Patent EP1572962. JD254839 - Sequence 235863 from Patent EP1572962. JD419194 - Sequence 400218 from Patent EP1572962. JD426283 - Sequence 407307 from Patent EP1572962. JD192952 - Sequence 173976 from Patent EP1572962. JD157606 - Sequence 138630 from Patent EP1572962. JD330160 - Sequence 311184 from Patent EP1572962. JD493999 - Sequence 475023 from Patent EP1572962. JD296152 - Sequence 277176 from Patent EP1572962. JD162558 - Sequence 143582 from Patent EP1572962. JD368248 - Sequence 349272 from Patent EP1572962. JD383027 - Sequence 364051 from Patent EP1572962. JD411225 - Sequence 392249 from Patent EP1572962. JD497617 - Sequence 478641 from Patent EP1572962. JD447816 - Sequence 428840 from Patent EP1572962. JD236781 - Sequence 217805 from Patent EP1572962. JD258079 - Sequence 239103 from Patent EP1572962. JD343526 - Sequence 324550 from Patent EP1572962. JD171731 - Sequence 152755 from Patent EP1572962. JD154389 - Sequence 135413 from Patent EP1572962. JD500495 - Sequence 481519 from Patent EP1572962. JD444314 - Sequence 425338 from Patent EP1572962. JD108303 - Sequence 89327 from Patent EP1572962. JD520119 - Sequence 501143 from Patent EP1572962. BC132957 - Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, mRNA (cDNA clone MGC:164588 IMAGE:40146979), complete cds. BC132959 - Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, mRNA (cDNA clone MGC:164590 IMAGE:40146981), complete cds. BC144234 - Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, mRNA (cDNA clone MGC:177771 IMAGE:9052754), complete cds. AK289735 - Homo sapiens cDNA FLJ75995 complete cds, highly similar to Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (KCNS1), mRNA. JD442610 - Sequence 423634 from Patent EP1572962. JD377512 - Sequence 358536 from Patent EP1572962. JD176351 - Sequence 157375 from Patent EP1572962. BC075033 - Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, mRNA (cDNA clone MGC:104009 IMAGE:30915420), complete cds. BC075034 - Homo sapiens potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1, mRNA (cDNA clone MGC:104165 IMAGE:30915626), complete cds. JD243529 - Sequence 224553 from Patent EP1572962. JD438084 - Sequence 419108 from Patent EP1572962. JD288837 - Sequence 269861 from Patent EP1572962. JD088726 - Sequence 69750 from Patent EP1572962. JD259467 - Sequence 240491 from Patent EP1572962. JD409933 - Sequence 390957 from Patent EP1572962. JD444079 - Sequence 425103 from Patent EP1572962. JD343874 - Sequence 324898 from Patent EP1572962. JD374236 - Sequence 355260 from Patent EP1572962. JD100586 - Sequence 81610 from Patent EP1572962. JD509546 - Sequence 490570 from Patent EP1572962. JD073884 - Sequence 54908 from Patent EP1572962. JD073883 - Sequence 54907 from Patent EP1572962. JD146144 - Sequence 127168 from Patent EP1572962. JD215316 - Sequence 196340 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96KK3 (Reactome details) participates in the following event(s):
US Server
