Human Gene PIGT (ENST00000279036.12) from GENCODE V44
Description: Homo sapiens phosphatidylinositol glycan anchor biosynthesis class T (PIGT), transcript variant 1, mRNA. (from RefSeq NM_015937) RefSeq Summary (NM_015937): This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000279036.12 Gencode Gene: ENSG00000124155.19 Transcript (Including UTRs) Position: hg38 chr20:45,416,141-45,426,241 Size: 10,101 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr20:45,416,157-45,425,826 Size: 9,670 Coding Exon Count: 12
ID:PIGT_HUMAN DESCRIPTION: RecName: Full=GPI transamidase component PIG-T; AltName: Full=Phosphatidylinositol-glycan biosynthesis class T protein; Flags: Precursor; FUNCTION: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. SUBUNIT: Forms a complex with PIGK/GPI8, PIGS, PIGU and GPAA1/GAA1. Has a critical role in maintaining the complex by stabilizing the expression of GPAA1 and GPI8 and linking them to PIGS. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. PTM: The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity. SIMILARITY: Belongs to the PIGT family. SEQUENCE CAUTION: Sequence=AAD27715.1; Type=Frameshift; Positions=5, 27; Sequence=AAQ88951.1; Type=Erroneous initiation; Sequence=CAB57341.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969N2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003923 GPI-anchor transamidase activity GO:0005515 protein binding
Biological Process: GO:0006506 GPI anchor biosynthetic process GO:0016255 attachment of GPI anchor to protein GO:0030182 neuron differentiation GO:0051402 neuron apoptotic process
US Server
