Human Gene ZNF217 (ENST00000371471.7) from GENCODE V44
  Description: Homo sapiens zinc finger protein 217 (ZNF217), transcript variant 2, mRNA. (from RefSeq NM_006526)
Gencode Transcript: ENST00000371471.7
Gencode Gene: ENSG00000171940.14
Transcript (Including UTRs)
   Position: hg38 chr20:53,567,071-53,593,839 Size: 26,769 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr20:53,571,744-53,582,826 Size: 11,083 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:53,567,071-53,593,839)mRNA (may differ from genome)Protein (1048 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN217_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 217;
FUNCTION: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
SUBUNIT: Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 7 C2H2-type zinc fingers.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/ZNF217ID42875ch20q13.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF217
Diseases sorted by gene-association score: ovarian serous cystadenocarcinoma (35), ovarian cystadenocarcinoma (23), ovarian clear cell carcinoma (12), ovary serous adenocarcinoma (9), ovarian benign neoplasm (9), ovary adenocarcinoma (6), ovarian cystadenoma (6), serous cystadenocarcinoma (6), cystadenocarcinoma (5), ovarian cancer, somatic (2), malignant ovarian surface epithelial-stromal neoplasm (1), ovary epithelial cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.82 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 274.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -135.80426-0.319 Picture PostScript Text
3' UTR -546.502217-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2HU2 - X-ray


ModBase Predicted Comparative 3D Structure on O75362
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0045892 negative regulation of transcription, DNA-templated

Cellular Component:
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  BC039055 - Homo sapiens, clone IMAGE:3447600, mRNA.
AF041259 - Homo sapiens breast cancer putative transcription factor (ZABC1) mRNA, complete cds.
JD278607 - Sequence 259631 from Patent EP1572962.
JD181847 - Sequence 162871 from Patent EP1572962.
JD363325 - Sequence 344349 from Patent EP1572962.
JD268396 - Sequence 249420 from Patent EP1572962.
JD224278 - Sequence 205302 from Patent EP1572962.
JD095500 - Sequence 76524 from Patent EP1572962.
JD359751 - Sequence 340775 from Patent EP1572962.
JD458049 - Sequence 439073 from Patent EP1572962.
JD528336 - Sequence 509360 from Patent EP1572962.
JD261181 - Sequence 242205 from Patent EP1572962.
JD259181 - Sequence 240205 from Patent EP1572962.
JD310491 - Sequence 291515 from Patent EP1572962.
BC113427 - Homo sapiens zinc finger protein 217, mRNA (cDNA clone MGC:141987 IMAGE:8322479), complete cds.
JD295047 - Sequence 276071 from Patent EP1572962.
KJ892426 - Synthetic construct Homo sapiens clone ccsbBroadEn_01820 ZNF217 gene, encodes complete protein.
AK290350 - Homo sapiens cDNA FLJ77047 partial cds, highly similar to Homo sapiens zinc finger protein 217 (ZNF217), mRNA.
JD080537 - Sequence 61561 from Patent EP1572962.
JD507491 - Sequence 488515 from Patent EP1572962.
JD061789 - Sequence 42813 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75362 (Reactome details) participates in the following event(s):

R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: E1P5Y6, ENST00000371471.1, ENST00000371471.2, ENST00000371471.3, ENST00000371471.4, ENST00000371471.5, ENST00000371471.6, NM_006526, O75362, Q14DB8, uc002xwq.1, uc002xwq.2, uc002xwq.3, uc002xwq.4, uc002xwq.5, uc002xwq.6, ZABC1, ZN217_HUMAN
UCSC ID: ENST00000371471.7
RefSeq Accession: NM_006526
Protein: O75362 (aka ZN217_HUMAN or Z217_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.