Human Gene PHACTR3 (ENST00000371015.6) from GENCODE V44
Description: Homo sapiens phosphatase and actin regulator 3 (PHACTR3), transcript variant 1, mRNA. (from RefSeq NM_080672) RefSeq Summary (NM_080672): This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000371015.6 Gencode Gene: ENSG00000087495.17 Transcript (Including UTRs) Position: hg38 chr20:59,604,540-59,847,711 Size: 243,172 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr20:59,605,015-59,847,130 Size: 242,116 Coding Exon Count: 13
ID:PHAR3_HUMAN DESCRIPTION: RecName: Full=Phosphatase and actin regulator 3; AltName: Full=Scaffold-associated PP1-inhibiting protein; Short=Scapinin; SUBUNIT: Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity. SUBCELLULAR LOCATION: Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions. TISSUE SPECIFICITY: Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL- 60 leukemia cells. INDUCTION: Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide. SIMILARITY: Belongs to the phosphatase and actin regulator family. SIMILARITY: Contains 4 RPEL repeats. SEQUENCE CAUTION: Sequence=CAC67489.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96KR7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.