Human Gene TIAM1 (ENST00000286827.7) from GENCODE V44
Description: Homo sapiens TIAM Rac1 associated GEF 1 (TIAM1), transcript variant 1, mRNA. (from RefSeq NM_003253) RefSeq Summary (NM_003253): This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000286827.7 Gencode Gene: ENSG00000156299.15 Transcript (Including UTRs) Position: hg38 chr21:31,118,416-31,558,977 Size: 440,562 Total Exon Count: 29 Strand: - Coding Region Position: hg38 chr21:31,120,368-31,266,972 Size: 146,605 Coding Exon Count: 25
ID:TIAM1_HUMAN DESCRIPTION: RecName: Full=T-lymphoma invasion and metastasis-inducing protein 1; Short=TIAM-1; FUNCTION: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. SUBUNIT: Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. SUBCELLULAR LOCATION: Cell junction. Note=Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. TISSUE SPECIFICITY: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. SIMILARITY: Belongs to the TIAM family. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 2 PH domains. SIMILARITY: Contains 1 RBD (Ras-binding) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TIAM1ID42557ch21q22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13009
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003300 cardiac muscle hypertrophy GO:0006915 apoptotic process GO:0007160 cell-matrix adhesion GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0008284 positive regulation of cell proliferation GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010976 positive regulation of neuron projection development GO:0016477 cell migration GO:0016601 Rac protein signal transduction GO:0030335 positive regulation of cell migration GO:0032092 positive regulation of protein binding GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0042220 response to cocaine GO:0043065 positive regulation of apoptotic process GO:0043507 positive regulation of JUN kinase activity GO:0048013 ephrin receptor signaling pathway GO:0050772 positive regulation of axonogenesis GO:0051056 regulation of small GTPase mediated signal transduction GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0061003 positive regulation of dendritic spine morphogenesis GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO:0070372 regulation of ERK1 and ERK2 cascade GO:0072657 protein localization to membrane GO:0090630 activation of GTPase activity GO:0098989 NMDA selective glutamate receptor signaling pathway GO:1904268 positive regulation of Schwann cell chemotaxis GO:1904338 regulation of dopaminergic neuron differentiation GO:1905274 regulation of modification of postsynaptic actin cytoskeleton GO:1990138 neuron projection extension GO:2000050 regulation of non-canonical Wnt signaling pathway
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