Human Gene GNAZ (ENST00000615612.2) from GENCODE V44
Description: Homo sapiens G protein subunit alpha z (GNAZ), mRNA. (from RefSeq NM_002073) RefSeq Summary (NM_002073): The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000615612.2 Gencode Gene: ENSG00000128266.9 Transcript (Including UTRs) Position: hg38 chr22:23,070,519-23,125,032 Size: 54,514 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr22:23,095,696-23,123,431 Size: 27,736 Coding Exon Count: 2
ID:GNAZ_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(z) subunit alpha; AltName: Full=G(x) alpha chain; AltName: Full=Gz-alpha; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19086
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC037333 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:43258 IMAGE:5264642), complete cds. BC026342 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:26547 IMAGE:4814858), complete cds. AK312519 - Homo sapiens cDNA, FLJ92884, Homo sapiens guanine nucleotide binding protein (G protein), alphaz polypeptide (GNAZ), mRNA. AK293653 - Homo sapiens cDNA FLJ51798 complete cds, highly similar to Guanine nucleotide-binding protein G(z) subunit alpha. BC078163 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:88028 IMAGE:6180193), complete cds. CR456495 - Homo sapiens GNAZ full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.GNAZ.V4). J03260 - Human transducin alpha-subunit (GNAZ) mRNA, complete cds. CU013380 - Homo sapiens GNAZ, mRNA (cDNA clone IMAGE:100000255), complete cds, without stop codon, in Gateway system. DQ892386 - Synthetic construct clone IMAGE:100005016; FLH185839.01X; RZPDo839F08148D guanine nucleotide binding protein (G protein), alpha z polypeptide (GNAZ) gene, encodes complete protein. EU176512 - Synthetic construct Homo sapiens clone IMAGE:100011490; FLH185838.01L; RZPDo839F05253D guanine nucleotide binding protein (G protein), alpha z polypeptide (GNAZ) gene, encodes complete protein. BC096828 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:111695 IMAGE:6519151), complete cds. CU013092 - Homo sapiens GNAZ, mRNA (cDNA clone IMAGE:100000351), complete cds, with stop codon, in Gateway system. AB463061 - Synthetic construct DNA, clone: pF1KB4667, Homo sapiens GNAZ gene for guanine nucleotide binding protein (G protein), alpha z polypeptide, without stop codon, in Flexi system. CU687322 - Synthetic construct Homo sapiens gateway clone IMAGE:100022954 5' read GNAZ mRNA. KJ896900 - Synthetic construct Homo sapiens clone ccsbBroadEn_06294 GNAZ gene, encodes complete protein. KJ896901 - Synthetic construct Homo sapiens clone ccsbBroadEn_06295 GNAZ gene, encodes complete protein. KJ896902 - Synthetic construct Homo sapiens clone ccsbBroadEn_06296 GNAZ gene, encodes complete protein. AF493899 - Homo sapiens guanine nucleotide binding protein alpha z (GNAZ) mRNA, complete cds. AK309397 - Homo sapiens cDNA, FLJ99438. JD541578 - Sequence 522602 from Patent EP1572962. JD419463 - Sequence 400487 from Patent EP1572962. JD261036 - Sequence 242060 from Patent EP1572962. JD432307 - Sequence 413331 from Patent EP1572962. JD151992 - Sequence 133016 from Patent EP1572962. JD323464 - Sequence 304488 from Patent EP1572962. JD477294 - Sequence 458318 from Patent EP1572962. JD193746 - Sequence 174770 from Patent EP1572962. JD450788 - Sequence 431812 from Patent EP1572962. JD097278 - Sequence 78302 from Patent EP1572962. JD423512 - Sequence 404536 from Patent EP1572962. JD069415 - Sequence 50439 from Patent EP1572962. JD409181 - Sequence 390205 from Patent EP1572962. JD503569 - Sequence 484593 from Patent EP1572962. JD357851 - Sequence 338875 from Patent EP1572962. JD494070 - Sequence 475094 from Patent EP1572962. JD353619 - Sequence 334643 from Patent EP1572962. JD110027 - Sequence 91051 from Patent EP1572962. JD528934 - Sequence 509958 from Patent EP1572962. JD245352 - Sequence 226376 from Patent EP1572962. JD083840 - Sequence 64864 from Patent EP1572962. JD458859 - Sequence 439883 from Patent EP1572962. JD443348 - Sequence 424372 from Patent EP1572962. JD394209 - Sequence 375233 from Patent EP1572962. JD162323 - Sequence 143347 from Patent EP1572962. JD229680 - Sequence 210704 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04730 - Long-term depression
Reactome (by CSHL, EBI, and GO)
Protein P19086 (Reactome details) participates in the following event(s):
R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392133 G alpha (z) auto-inactivates by hydrolysing GTP to GDP R-HSA-8982703 PKC binds active G alpha (z) R-HSA-751024 The Ligand:GPCR:Gz complex dissociates R-HSA-750988 Inactive G alpha (z) reassociates with G beta:gamma R-HSA-8850560 G-protein alpha releases G-protein heterotrimer from PDCL R-HSA-8982709 G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) R-HSA-751040 PKC phosphorylates G alpha (z) R-HSA-749446 Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit R-HSA-112037 Inactivation of PLC beta R-HSA-167415 G-protein alpha subunit is inactivated R-HSA-111870 Activation of PLC beta-1/4 R-HSA-112271 The receptor:G-protein complex dissociates R-HSA-167429 The receptor:G-protein complex binds GTP R-HSA-749453 Liganded Gz-activating GPCR acts as a GEF for Gz R-HSA-167408 The high affinity receptor complex binds to G-protein R-HSA-167419 The receptor:G-protein complex releases GDP R-HSA-111879 PIP2 hydrolysis R-HSA-418597 G alpha (z) signalling events R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-388396 GPCR downstream signalling R-HSA-202040 G-protein activation R-HSA-112043 PLC beta mediated events R-HSA-390466 Chaperonin-mediated protein folding R-HSA-372790 Signaling by GPCR R-HSA-111885 Opioid Signalling R-HSA-112040 G-protein mediated events R-HSA-391251 Protein folding R-HSA-162582 Signal Transduction R-HSA-418594 G alpha (i) signalling events R-HSA-392499 Metabolism of proteins
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