Human Gene ST13 (ENST00000216218.8) from GENCODE V44
Description: Homo sapiens ST13 Hsp70 interacting protein (ST13), transcript variant 1, mRNA. (from RefSeq NM_003932) RefSeq Summary (NM_003932): The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. Gencode Transcript: ENST00000216218.8 Gencode Gene: ENSG00000100380.15 Transcript (Including UTRs) Position: hg38 chr22:40,824,535-40,856,639 Size: 32,105 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr22:40,826,538-40,856,540 Size: 30,003 Coding Exon Count: 12
ID:F10A1_HUMAN DESCRIPTION: RecName: Full=Hsc70-interacting protein; Short=Hip; AltName: Full=Aging-associated protein 2; AltName: Full=Progesterone receptor-associated p48 protein; AltName: Full=Protein FAM10A1; AltName: Full=Putative tumor suppressor ST13; AltName: Full=Renal carcinoma antigen NY-REN-33; AltName: Full=Suppression of tumorigenicity 13 protein; FUNCTION: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). SUBUNIT: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5. INTERACTION: P02649:APOE; NbExp=3; IntAct=EBI-357285, EBI-1222467; P29474:NOS3; NbExp=3; IntAct=EBI-357285, EBI-1391623; P49768:PSEN1; NbExp=3; IntAct=EBI-357285, EBI-297277; SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Belongs to the FAM10 family. SIMILARITY: Contains 1 STI1 domain. SIMILARITY: Contains 3 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50502
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0051085 chaperone mediated protein folding requiring cofactor GO:0051260 protein homooligomerization GO:0051289 protein homotetramerization GO:0061084 negative regulation of protein refolding
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