Human Gene CAPN7 (ENST00000253693.7) from GENCODE V44
Description: Homo sapiens calpain 7 (CAPN7), transcript variant 14, non-coding RNA. (from RefSeq NR_164767) RefSeq Summary (NM_014296): Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000253693.7 Gencode Gene: ENSG00000131375.10 Transcript (Including UTRs) Position: hg38 chr3:15,206,246-15,252,916 Size: 46,671 Total Exon Count: 21 Strand: + Coding Region Position: hg38 chr3:15,206,496-15,251,260 Size: 44,765 Coding Exon Count: 21
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01067 - Calpain large subunit, domain III PF04212 - MIT (microtubule interacting and transport) domain PF00648 - Calpain family cysteine protease
ModBase Predicted Comparative 3D Structure on Q9Y6W3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
