ID:TGM4_HUMAN DESCRIPTION: RecName: Full=Protein-glutamine gamma-glutamyltransferase 4; EC=2.3.2.13; AltName: Full=Fibrinoligase; AltName: Full=Prostate transglutaminase; AltName: Full=Prostate-specific transglutaminase; AltName: Full=Transglutaminase P; Short=TG(P); Short=TGP; Short=TGase P; AltName: Full=Transglutaminase-4; Short=TGase-4; FUNCTION: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract. CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)- alkylglutamine + NH(3). COFACTOR: Binds 1 calcium ion per subunit (By similarity). SUBUNIT: Homodimer (By similarity). TISSUE SPECIFICITY: Prostate. SIMILARITY: Belongs to the transglutaminase superfamily. Transglutaminase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00927 - Transglutaminase family, C-terminal ig like domain PF01841 - Transglutaminase-like superfamily PF00868 - Transglutaminase family
ModBase Predicted Comparative 3D Structure on P49221
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
