Human Gene ITIH4 (ENST00000266041.9) from GENCODE V44
Description: Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA. (from RefSeq NM_002218) RefSeq Summary (NM_002218): The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. Gencode Transcript: ENST00000266041.9 Gencode Gene: ENSG00000055955.17 Transcript (Including UTRs) Position: hg38 chr3:52,812,962-52,830,672 Size: 17,711 Total Exon Count: 24 Strand: - Coding Region Position: hg38 chr3:52,813,421-52,830,642 Size: 17,222 Coding Exon Count: 24
ID:ITIH4_HUMAN DESCRIPTION: RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H4; Short=ITI heavy chain H4; Short=ITI-HC4; Short=Inter-alpha-inhibitor heavy chain 4; AltName: Full=Inter-alpha-trypsin inhibitor family heavy chain-related protein; Short=IHRP; AltName: Full=Plasma kallikrein sensitive glycoprotein 120; Short=Gp120; Short=PK-120; Contains: RecName: Full=70 kDa inter-alpha-trypsin inhibitor heavy chain H4; Contains: RecName: Full=35 kDa inter-alpha-trypsin inhibitor heavy chain H4; Flags: Precursor; FUNCTION: May be involved in acute phase reactions. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Liver specific. INDUCTION: Levels increase significantly in the sera of patients after different surgical trauma. PTM: Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. PTM: Appears to be both N- and O-glycosylated. The O-linked polysaccharides on Ser-696, Thr-701 and Ser-702 are probably the mucin type linked to GalNAc. O-linked glycosylations in the region AA 719-725 consist of core 1 or possibly core 8 glycans. SIMILARITY: Belongs to the ITIH family. SIMILARITY: Contains 1 VIT domain. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06668 - Inter-alpha-trypsin inhibitor heavy chain C-terminus PF08487 - Vault protein inter-alpha-trypsin domain PF00092 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on Q14624
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.