Human Gene CD200 (ENST00000473539.5) from GENCODE V44
  Description: Homo sapiens CD200 molecule (CD200), transcript variant 11, non-coding RNA. (from RefSeq NR_158642)
RefSeq Summary (NM_001004196): This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gencode Transcript: ENST00000473539.5
Gencode Gene: ENSG00000091972.18
Transcript (Including UTRs)
   Position: hg38 chr3:112,333,156-112,362,132 Size: 28,977 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr3:112,333,213-112,361,550 Size: 28,338 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:112,333,156-112,362,132)mRNA (may differ from genome)Protein (294 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OX2G_HUMAN
DESCRIPTION: RecName: Full=OX-2 membrane glycoprotein; AltName: CD_antigen=CD200; Flags: Precursor;
FUNCTION: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
SUBUNIT: Interacts with CD200R1.
INTERACTION: Q8TD46:CD200R1; NbExp=2; IntAct=EBI-3910563, EBI-4314412;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/CD200ID44381ch3q13.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CD200
Diseases sorted by gene-association score: mantle cell lymphoma (3), primary hypertrophic osteoarthropathy (2), hypotropia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.76 RPKM in Brain - Hypothalamus
Total median expression: 524.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.9057-0.367 Picture PostScript Text
3' UTR -149.90582-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain

ModBase Predicted Comparative 3D Structure on P41217
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0050839 cell adhesion molecule binding

Biological Process:
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0008037 cell recognition
GO:0043031 negative regulation of macrophage activation
GO:0050776 regulation of immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK312563 - Homo sapiens cDNA, FLJ92938.
AK297194 - Homo sapiens cDNA FLJ55225 complete cds, highly similar to Homo sapiens CD200 molecule (CD200), transcript variant 2, mRNA.
BC022522 - Homo sapiens CD200 molecule, mRNA (cDNA clone MGC:26657 IMAGE:4794050), complete cds.
AF063591 - Homo sapiens brain my033 protein mRNA, complete cds.
AL832529 - Homo sapiens mRNA; cDNA DKFZp547E1816 (from clone DKFZp547E1816).
AK293399 - Homo sapiens cDNA FLJ61211 complete cds, highly similar to OX-2 membrane glycoprotein precursor.
AK129797 - Homo sapiens cDNA FLJ26286 fis, clone DMC06841, highly similar to OX-2 membrane glycoprotein precursor.
BC031103 - Homo sapiens CD200 molecule, mRNA (cDNA clone MGC:33959 IMAGE:5301702), complete cds.
AK074972 - Homo sapiens cDNA FLJ90491 fis, clone NT2RP3003532, highly similar to OX-2 MEMBRANE GLYCOPROTEIN PRECURSOR.
CU692670 - Synthetic construct Homo sapiens gateway clone IMAGE:100018679 5' read CD200 mRNA.
AY603771 - Homo sapiens CD200 antigen (MOX2) mRNA, complete cds.
DQ892368 - Synthetic construct clone IMAGE:100004998; FLH185636.01X; RZPDo839D04148D CD200 molecule (CD200) gene, encodes complete protein.
DQ895577 - Synthetic construct Homo sapiens clone IMAGE:100010037; FLH185632.01L; RZPDo839D04147D CD200 molecule (CD200) gene, encodes complete protein.
EU831904 - Synthetic construct Homo sapiens clone HAIB:100066933; DKFZo008A0423 CD200 molecule protein (CD200) gene, encodes complete protein.
KJ897199 - Synthetic construct Homo sapiens clone ccsbBroadEn_06593 CD200 gene, encodes complete protein.
JD049536 - Sequence 30560 from Patent EP1572962.
JD549583 - Sequence 530607 from Patent EP1572962.
JD185645 - Sequence 166669 from Patent EP1572962.
JD552386 - Sequence 533410 from Patent EP1572962.
JD421230 - Sequence 402254 from Patent EP1572962.
JD094031 - Sequence 75055 from Patent EP1572962.
JD483627 - Sequence 464651 from Patent EP1572962.
JD072764 - Sequence 53788 from Patent EP1572962.
JD146985 - Sequence 128009 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P41217 (Reactome details) participates in the following event(s):

R-HSA-199154 CD200 binds to CD200R
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQI1, B4DLW9, D3DN65, ENST00000473539.1, ENST00000473539.2, ENST00000473539.3, ENST00000473539.4, MOX1, MOX2, My033, NR_158642, OX2G_HUMAN, P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3, uc003dyw.1, uc003dyw.2, uc003dyw.3, uc003dyw.4
UCSC ID: ENST00000473539.5
RefSeq Accession: NM_001004196
Protein: P41217 (aka OX2G_HUMAN)
CCDS: CCDS33818.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.