Human Gene TIGIT (ENST00000383671.8) from GENCODE V44
Description: Homo sapiens T cell immunoreceptor with Ig and ITIM domains (TIGIT), mRNA. (from RefSeq NM_173799) RefSeq Summary (NM_173799): This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000383671.8 Gencode Gene: ENSG00000181847.12 Transcript (Including UTRs) Position: hg38 chr3:114,294,028-114,310,288 Size: 16,261 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr3:114,294,062-114,308,131 Size: 14,070 Coding Exon Count: 4
ID:TIGIT_HUMAN DESCRIPTION: RecName: Full=T-cell immunoreceptor with Ig and ITIM domains; AltName: Full=V-set and immunoglobulin domain-containing protein 9; AltName: Full=V-set and transmembrane domain-containing protein 3; Flags: Precursor; FUNCTION: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. SUBUNIT: Binds with high affinity to PVR and with lower affinity to PVRL2 and PVRL3. INTERACTION: Q9NQS3:PVRL3; NbExp=2; IntAct=EBI-4314807, EBI-2826725; Q96NY8:PVRL4; NbExp=2; IntAct=EBI-4314807, EBI-4314784; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=CAI46183.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q495A1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.