Human Gene PDIA5 (ENST00000316218.12) from GENCODE V44
Description: Homo sapiens protein disulfide isomerase family A member 5 (PDIA5), transcript variant 1, mRNA. (from RefSeq NM_006810) RefSeq Summary (NM_006810): This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]. Gencode Transcript: ENST00000316218.12 Gencode Gene: ENSG00000065485.20 Transcript (Including UTRs) Position: hg38 chr3:123,067,025-123,162,104 Size: 95,080 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr3:123,067,165-123,161,960 Size: 94,796 Coding Exon Count: 17
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14554
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC001625 - Homo sapiens protein disulfide isomerase family A, member 5, mRNA (cDNA clone MGC:1259 IMAGE:3537659), complete cds. D49490 - Homo sapiens mRNA for protein disulfide isomerase-related protein (PDIR), complete cds. KJ900838 - Synthetic construct Homo sapiens clone ccsbBroadEn_10232 PDIA5 gene, encodes complete protein. JD217424 - Sequence 198448 from Patent EP1572962. JD141807 - Sequence 122831 from Patent EP1572962. JD339785 - Sequence 320809 from Patent EP1572962. AK054963 - Homo sapiens cDNA FLJ30401 fis, clone BRACE2008443, highly similar to PROTEIN DISULFIDE ISOMERASE-RELATED PROTEIN PRECURSOR (EC 5.3.4.1). JD554405 - Sequence 535429 from Patent EP1572962. JD162108 - Sequence 143132 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q14554 (Reactome details) participates in the following event(s):