ID:CSTN2_HUMAN DESCRIPTION: RecName: Full=Calsyntenin-2; AltName: Full=Alcadein-gamma; Short=Alc-gamma; Flags: Precursor; FUNCTION: May modulate calcium-mediated postsynaptic signals (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization (By similarity). TISSUE SPECIFICITY: Restricted to the brain. DOMAIN: Binds synaptic Ca(2+) with its cytoplasmic domain (By similarity). PTM: Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N- terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (By similarity). SIMILARITY: Contains 2 cadherin domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H4D0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.