Human Gene TRPC1 (ENST00000476941.6) from GENCODE V44
Description: Homo sapiens transient receptor potential cation channel subfamily C member 1 (TRPC1), transcript variant 1, mRNA. (from RefSeq NM_001251845) RefSeq Summary (NM_001251845): The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000476941.6 Gencode Gene: ENSG00000144935.17 Transcript (Including UTRs) Position: hg38 chr3:142,724,034-142,807,888 Size: 83,855 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr3:142,724,560-142,806,235 Size: 81,676 Coding Exon Count: 13
ID:TRPC1_HUMAN DESCRIPTION: RecName: Full=Short transient receptor potential channel 1; Short=TrpC1; AltName: Full=Transient receptor protein 1; Short=TRP-1; FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. SUBUNIT: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Seems to be ubiquitous. SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. SIMILARITY: Contains 4 ANK repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12796 - Ankyrin repeats (3 copies) PF00520 - Ion transport protein PF08344 - Transient receptor ion channel II
ModBase Predicted Comparative 3D Structure on P48995
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.