Human Gene TRPC1 (ENST00000476941.6) from GENCODE V44
  Description: Homo sapiens transient receptor potential cation channel subfamily C member 1 (TRPC1), transcript variant 1, mRNA. (from RefSeq NM_001251845)
RefSeq Summary (NM_001251845): The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gencode Transcript: ENST00000476941.6
Gencode Gene: ENSG00000144935.17
Transcript (Including UTRs)
   Position: hg38 chr3:142,724,034-142,807,888 Size: 83,855 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr3:142,724,560-142,806,235 Size: 81,676 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:142,724,034-142,807,888)mRNA (may differ from genome)Protein (793 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Short transient receptor potential channel 1; Short=TrpC1; AltName: Full=Transient receptor protein 1; Short=TRP-1;
FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
SUBUNIT: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Seems to be ubiquitous.
SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
SIMILARITY: Contains 4 ANK repeats.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.52 RPKM in Ovary
Total median expression: 241.43 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -286.00526-0.544 Picture PostScript Text
3' UTR -342.001653-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR005821 - Ion_trans_dom
IPR004729 - TRP_channel
IPR013555 - TRP_dom
IPR005457 - TRPC1_channel
IPR002153 - TRPC_channel

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)
PF00520 - Ion transport protein
PF08344 - Transient receptor ion channel II

ModBase Predicted Comparative 3D Structure on P48995
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0044325 ion channel binding
GO:0070679 inositol 1,4,5 trisphosphate binding

Biological Process:
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0042438 melanin biosynthetic process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:1903779 regulation of cardiac conduction

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex

-  Descriptions from all associated GenBank mRNAs
  LF208584 - JP 2014500723-A/16087: Polycomb-Associated Non-Coding RNAs.
MA444161 - JP 2018138019-A/16087: Polycomb-Associated Non-Coding RNAs.
U31110 - Human alternatively spliced trp-1 protein and unspliced trp-1 protein (trp-1) mRNA, complete cds.
Z73903 - H.sapiens mRNA for TRPC1A.
X89066 - H.sapiens mRNA for TRPC1 protein.
BC112338 - Homo sapiens transient receptor potential cation channel, subfamily C, member 1, mRNA (cDNA clone MGC:133334 IMAGE:40067810), complete cds.
BC113953 - Homo sapiens transient receptor potential cation channel, subfamily C, member 1, mRNA (cDNA clone MGC:133335 IMAGE:40067811), complete cds.
KJ892319 - Synthetic construct Homo sapiens clone ccsbBroadEn_01713 TRPC1 gene, encodes complete protein.
AB255425 - Homo sapiens TRPC1 mRNA for transient receptor potential cation channel, subfamily C, member 1, short isoform, complete cds.
JD466530 - Sequence 447554 from Patent EP1572962.
JD481798 - Sequence 462822 from Patent EP1572962.
JD395949 - Sequence 376973 from Patent EP1572962.
EF522961 - Homo sapiens TRPC1 splice variant mRNA, partial cds, alternatively spliced.
GQ293239 - Homo sapiens transient receptor potential canonical 1 mRNA, partial cds, alternatively spliced.
JD092876 - Sequence 73900 from Patent EP1572962.
LF378132 - JP 2014500723-A/185635: Polycomb-Associated Non-Coding RNAs.
MA613709 - JP 2018138019-A/185635: Polycomb-Associated Non-Coding RNAs.
JD058675 - Sequence 39699 from Patent EP1572962.
JD273555 - Sequence 254579 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway

BioCyc Knowledge Library
PWY-6498 - eumelanin biosynthesis

Reactome (by CSHL, EBI, and GO)

Protein P48995 (Reactome details) participates in the following event(s):

R-HSA-2089927 STIM1 binds TRPC1 forming STIM1:TRPC1 complex
R-HSA-3295579 TRPs transport extracellular Ca2+ to cytosol
R-HSA-2089943 TRPC1 translocates calcium from the extracellular region to the cytosol
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-3295583 TRP channels
R-HSA-5578775 Ion homeostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-373752 Netrin-1 signaling
R-HSA-2672351 Stimuli-sensing channels
R-HSA-5576891 Cardiac conduction
R-HSA-168256 Immune System
R-HSA-422475 Axon guidance
R-HSA-983712 Ion channel transport
R-HSA-397014 Muscle contraction
R-HSA-1266738 Developmental Biology
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000476941.1, ENST00000476941.2, ENST00000476941.3, ENST00000476941.4, ENST00000476941.5, NM_001251845, P48995, Q14CE4, TRP1, TRPC1_HUMAN, uc003evc.1, uc003evc.2, uc003evc.3, uc003evc.4, uc003evc.5
UCSC ID: ENST00000476941.6
RefSeq Accession: NM_001251845
Protein: P48995 (aka TRPC1_HUMAN or TRP1_HUMAN)
CCDS: CCDS3126.1, CCDS58856.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.