Human Gene SUCNR1 (ENST00000362032.6) from GENCODE V44
  Description: Homo sapiens succinate receptor 1 (SUCNR1), mRNA. (from RefSeq NM_033050)
RefSeq Summary (NM_033050): This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000362032.6
Gencode Gene: ENSG00000198829.6
Transcript (Including UTRs)
   Position: hg38 chr3:151,873,643-151,884,619 Size: 10,977 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr3:151,879,893-151,881,548 Size: 1,656 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:151,873,643-151,884,619)mRNA (may differ from genome)Protein (334 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SUCR1_HUMAN
DESCRIPTION: RecName: Full=Succinate receptor 1; AltName: Full=G-protein coupled receptor 91; AltName: Full=P2Y purinoceptor 1-like;
FUNCTION: Receptor for succinate.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed specifically in kidney.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
SEQUENCE CAUTION: Sequence=AAK29080.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SUCNR1
Diseases sorted by gene-association score: exudative vitreoretinopathy 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.82 RPKM in Thyroid
Total median expression: 19.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.40105-0.290 Picture PostScript Text
3' UTR -660.203071-0.215 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q9BXA5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0038023 signaling receptor activity

Biological Process:
GO:0002001 renin secretion into blood stream
GO:0002281 macrophage activation involved in immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008150 biological_process
GO:0032611 interleukin-1 beta production
GO:0042593 glucose homeostasis
GO:0050729 positive regulation of inflammatory response
GO:0050921 positive regulation of chemotaxis
GO:0051592 response to calcium ion
GO:0060177 regulation of angiotensin metabolic process

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LP895451 - Sequence 315 from Patent EP3253886.
AK290420 - Homo sapiens cDNA FLJ75637 complete cds, highly similar to Homo sapiens succinate receptor 1 (SUCNR1), mRNA.
BC030948 - Homo sapiens succinate receptor 1, mRNA (cDNA clone MGC:32514 IMAGE:4594810), complete cds.
AF247785 - Homo sapiens P2Y purinoceptor 1 mRNA, complete cds.
AF348078 - Homo sapiens G-protein coupled receptor 91 (GPR91) mRNA, complete cds.
CU689042 - Synthetic construct Homo sapiens gateway clone IMAGE:100022248 5' read SUCNR1 mRNA.
KJ894342 - Synthetic construct Homo sapiens clone ccsbBroadEn_03736 SUCNR1 gene, encodes complete protein.
EU432110 - Homo sapiens succinate receptor 1 (SUCNR1) mRNA, complete cds.
DQ895895 - Synthetic construct Homo sapiens clone IMAGE:100010355; FLH188698.01L; RZPDo839F0263D succinate receptor 1 (SUCNR1) gene, encodes complete protein.
JD039966 - Sequence 20990 from Patent EP1572962.
JD537527 - Sequence 518551 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BXA5 (Reactome details) participates in the following event(s):

R-HSA-3296244 SUCNR1 binds SUCCA
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K305, ENST00000362032.1, ENST00000362032.2, ENST00000362032.3, ENST00000362032.4, ENST00000362032.5, GPR91, NM_033050, Q8TDQ8, Q9BXA5, SUCR1_HUMAN, uc003ezf.1, uc003ezf.2, uc003ezf.3
UCSC ID: ENST00000362032.6
RefSeq Accession: NM_033050
Protein: Q9BXA5 (aka SUCR1_HUMAN)
CCDS: CCDS3162.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.