Human Gene IL12A (ENST00000305579.7) from GENCODE V44
Description: Homo sapiens interleukin 12A (IL12A), transcript variant 1, mRNA. (from RefSeq NM_000882) RefSeq Summary (NM_000882): This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000305579.7 Gencode Gene: ENSG00000168811.8 Transcript (Including UTRs) Position: hg38 chr3:159,988,835-159,996,019 Size: 7,185 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr3:159,989,057-159,995,559 Size: 6,503 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60595
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
