Human Gene SMC4 (ENST00000357388.8) from GENCODE V44
Description: Homo sapiens structural maintenance of chromosomes 4 (SMC4), transcript variant 2, mRNA. (from RefSeq NM_001002800) RefSeq Summary (NM_001002800): This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]. Gencode Transcript: ENST00000357388.8 Gencode Gene: ENSG00000113810.16 Transcript (Including UTRs) Position: hg38 chr3:160,399,650-160,434,953 Size: 35,304 Total Exon Count: 24 Strand: + Coding Region Position: hg38 chr3:160,400,827-160,433,809 Size: 32,983 Coding Exon Count: 23
ID:SMC4_HUMAN DESCRIPTION: RecName: Full=Structural maintenance of chromosomes protein 4; Short=SMC protein 4; Short=SMC-4; AltName: Full=Chromosome-associated polypeptide C; Short=hCAP-C; AltName: Full=XCAP-C homolog; FUNCTION: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. SUBUNIT: Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. TISSUE SPECIFICITY: Widely expressed. Higher expression in testis, colon, thymus. DOMAIN: The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer (By similarity). SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06470 - SMC proteins Flexible Hinge Domain PF02463 - RecF/RecN/SMC N terminal domain
ModBase Predicted Comparative 3D Structure on Q9NTJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
