Human Gene HTR3C (ENST00000318351.2) from GENCODE V44
Description: Homo sapiens 5-hydroxytryptamine receptor 3C (HTR3C), mRNA. (from RefSeq NM_130770) RefSeq Summary (NM_130770): The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000318351.2 Gencode Gene: ENSG00000178084.2 Transcript (Including UTRs) Position: hg38 chr3:184,053,047-184,060,673 Size: 7,627 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr3:184,053,081-184,060,352 Size: 7,272 Coding Exon Count: 9
ID:5HT3C_HUMAN DESCRIPTION: RecName: Full=5-hydroxytryptamine receptor 3C; Short=5-HT3-C; Short=5-HT3C; AltName: Full=Serotonin receptor 3C; Flags: Precursor; FUNCTION: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. SUBUNIT: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. TISSUE SPECIFICITY: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXA8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005515 protein binding GO:0022850 serotonin-gated cation channel activity
Biological Process: GO:0006811 ion transport GO:0007165 signal transduction GO:0007210 serotonin receptor signaling pathway GO:0034220 ion transmembrane transport
AF459285 - Homo sapiens 5-hydroxytryptamine receptor 3 subunit C (HTR3C) mRNA, complete cds. BC131799 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member C, mRNA (cDNA clone MGC:156912 IMAGE:40069671), complete cds. JD103594 - Sequence 84618 from Patent EP1572962. JD079341 - Sequence 60365 from Patent EP1572962. KJ895760 - Synthetic construct Homo sapiens clone ccsbBroadEn_05154 HTR3C gene, encodes complete protein. JD161157 - Sequence 142181 from Patent EP1572962. JD201682 - Sequence 182706 from Patent EP1572962. JD458841 - Sequence 439865 from Patent EP1572962. JD130178 - Sequence 111202 from Patent EP1572962. JD307429 - Sequence 288453 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8WXA8 (Reactome details) participates in the following event(s):
R-HSA-975311 HTR3 pentamer:5HT transports Na+,K+, and Ca2+ R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System