Human Gene FGF12 (ENST00000454309.6) Description and Page Index
Description: Homo sapiens fibroblast growth factor 12 (FGF12), transcript variant 1, mRNA. (from RefSeq NM_021032) RefSeq Summary (NM_021032): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000454309.6 Gencode Gene: ENSG00000114279.13 Transcript (Including UTRs) Position: hg38 chr3:192,142,509-192,409,049 Size: 266,541 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr3:192,144,009-192,408,223 Size: 264,215 Coding Exon Count: 5
ID:FGF12_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 12; Short=FGF-12; AltName: Full=Fibroblast growth factor homologous factor 1; Short=FHF-1; AltName: Full=Myocyte-activating factor; FUNCTION: Probably involved in nervous system development and function. SUBUNIT: Interacts with the C-terminal region of SCN9A (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures. SIMILARITY: Belongs to the heparin-binding growth factors family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61328
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.