Human Gene FGFBP1 (ENST00000382333.2) from GENCODE V44
Description: Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA. (from RefSeq NM_005130) RefSeq Summary (NM_005130): This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]. Gencode Transcript: ENST00000382333.2 Gencode Gene: ENSG00000137440.5 Transcript (Including UTRs) Position: hg38 chr4:15,935,577-15,938,740 Size: 3,164 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr4:15,935,928-15,936,632 Size: 705 Coding Exon Count: 1
ID:FGFP1_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor-binding protein 1; Short=FGF-BP; Short=FGF-BP1; Short=FGF-binding protein 1; Short=FGFBP-1; AltName: Full=17 kDa heparin-binding growth factor-binding protein; Short=17 kDa HBGF-binding protein; Short=HBp17; Flags: Precursor; FUNCTION: Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. SUBUNIT: Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2. INTERACTION: P09038:FGF2; NbExp=3; IntAct=EBI-953742, EBI-977447; SUBCELLULAR LOCATION: Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. TISSUE SPECIFICITY: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo- epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. INDUCTION: Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens. MISCELLANEOUS: Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors. SIMILARITY: Belongs to the fibroblast growth factor-binding protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06473 - FGF binding protein 1 (FGF-BP1)
ModBase Predicted Comparative 3D Structure on Q14512
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.