Human Gene REST (ENST00000619101.5) from GENCODE V44
  Description: RE1 silencing transcription factor (from HGNC REST)
RefSeq Summary (NM_001193508): This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000619101.5
Gencode Gene: ENSG00000084093.19
Transcript (Including UTRs)
   Position: hg38 chr4:56,909,016-56,935,844 Size: 26,829 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr4:56,910,639-56,927,655 Size: 17,017 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
GeneReviewsMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:56,909,016-56,935,844)mRNA (may differ from genome)Protein (340 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: REST
Diseases sorted by gene-association score: wilms tumor 6* (905), fibromatosis, gingival, 5* (900), wilms tumor susceptibility-5* (8), hereditary wilms' tumor (7), gingival fibromatosis (7), huntington disease (4), medulloblastoma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.39 RPKM in Testis
Total median expression: 178.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.9033-0.179 Picture PostScript Text
3' UTR -1581.706013-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC038985 - Homo sapiens, Similar to RE1-silencing transcription factor, clone IMAGE:5785778, mRNA, partial cds.
U13879 - Human neuron-restrictive silencer factor mRNA, partial cds.
JX896991 - Homo sapiens RE1-silencing transcription factor variant E1a/E2a/E2k (REST) mRNA, complete cds, alternatively spliced.
JX896957 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/E4c (REST) mRNA, complete cds, alternatively spliced.
JX896958 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4 (REST) mRNA, complete cds, alternatively spliced.
JX896959 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E4 (REST) mRNA, partial cds, alternatively spliced.
JX896960 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896962 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/N3c/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896963 - Homo sapiens RE1-silencing transcription factor variant E1a/N2a/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896964 - Homo sapiens RE1-silencing transcription factor variant E1a/N2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896965 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896961 - Homo sapiens RE1-silencing transcription factor variant E1a/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
KC117266 - Homo sapiens RE1-silencing transcription factor variant E1a/E2l/E2i/E3/E4j (REST) mRNA, complete cds, alternatively spliced.
JX896971 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i (REST) mRNA, complete cds, alternatively spliced.
JX896972 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E4b/E4d non-coding RNA (REST), complete sequence, alternatively spliced.
JX896973 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E4i non-coding RNA (REST), complete sequence, alternatively spliced.
JX896974 - Homo sapiens RE1-silencing transcription factor variant E1a/E4i non-coding RNA (REST), complete sequence, alternatively spliced.
JX896975 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E2i/E3/E4i non-coding RNA (REST), complete sequence, alternatively spliced.
JX896976 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E4f/E4i non-coding RNA (REST), complete sequence, alternatively spliced.
JX896977 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E4i non-coding RNA (REST), complete sequence, alternatively spliced.
JX896978 - Homo sapiens RE1-silencing transcription factor variant E1a/E2d/E4g (REST) mRNA, complete cds, alternatively spliced.
JX896979 - Homo sapiens RE1-silencing transcription factor variant E1a/E2e/E4h (REST) mRNA, complete cds, alternatively spliced.
JX896980 - Homo sapiens RE1-silencing transcription factor variant E1a/E2f/E4e (REST) mRNA, complete cds, alternatively spliced.
JX896984 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E5 (REST) mRNA, complete cds, alternatively spliced.
JX896985 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E5 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896983 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/E5 (REST) mRNA, complete cds, alternatively spliced.
KF429249 - Homo sapiens REST/EAPP fusion protein mRNA, complete cds.
BC132859 - Homo sapiens RE1-silencing transcription factor, mRNA (cDNA clone MGC:164490 IMAGE:40146881), complete cds.
BC136491 - Homo sapiens RE1-silencing transcription factor, mRNA (cDNA clone MGC:168103 IMAGE:9020480), complete cds.
AB209750 - Homo sapiens mRNA for RE1-silencing transcription factor variant protein.
BC017822 - Homo sapiens RE1-silencing transcription factor, mRNA (cDNA clone IMAGE:4690075), partial cds.
JX896992 - Homo sapiens RE1-silencing transcription factor variant E1b/E2a/E2k (REST) mRNA, complete cds, alternatively spliced.
JX896966 - Homo sapiens RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4 (REST) mRNA, complete cds, alternatively spliced.
JX896968 - Homo sapiens RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4 (REST) mRNA, partial cds, alternatively spliced.
JX896969 - Homo sapiens RE1-silencing transcription factor variant E1b/N1/E2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
KC117263 - Homo sapiens RE1-silencing transcription factor variant E1b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896981 - Homo sapiens RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i (REST) mRNA, complete cds, alternatively spliced.
JX896982 - Homo sapiens RE1-silencing transcription factor variant E1b/E2e/E4h (REST) mRNA, complete cds, alternatively spliced.
JX896989 - Homo sapiens RE1-silencing transcription factor variant E1b/E2/E3/E5 (REST) mRNA, complete cds, alternatively spliced.
KC117265 - Homo sapiens RE1-silencing transcription factor variant E1b/E3/E5 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896993 - Homo sapiens RE1-silencing transcription factor variant E1c/E2a/E2k (REST) mRNA, complete cds, alternatively spliced.
JX896970 - Homo sapiens RE1-silencing transcription factor variant E1c/E2g/E3/E4 (REST) mRNA, partial cds, alternatively spliced.
KC117264 - Homo sapiens RE1-silencing transcription factor variant E1c/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JX896990 - Homo sapiens RE1-silencing transcription factor variant E1c/E2/E3/E5 (REST) mRNA, complete cds, alternatively spliced.
U13877 - Human neural-restrictive silencer factor, splice variant mRNA, partial cds.
U22314 - Human REST protein mRNA, complete cds.
AB385046 - Synthetic construct DNA, clone: pF1KB5115, Homo sapiens REST gene for RE1-silencing transcription factor, complete cds, without stop codon, in Flexi system.
JX896967 - Homo sapiens RE1-silencing transcription factor variant E1b/E2b/E2h/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
AF228045 - Homo sapiens truncated neuron restrictive silencer factor isoform (REST) mRNA, partial cds.
KC117262 - Homo sapiens RE1-silencing transcription factor variant E1b/E2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.
JD042692 - Sequence 23716 from Patent EP1572962.
DL490548 - Novel nucleic acids.
U22680 - Human X2 box repressor mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087X1C2, ENST00000619101.1, ENST00000619101.2, ENST00000619101.3, ENST00000619101.4, U22680, uc003hci.1, uc003hci.2, uc003hci.3, uc003hci.4, uc003hci.5
UCSC ID: ENST00000619101.5
RefSeq Accession: NM_001193508

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene REST:
wilms-ov (Wilms Tumor Predisposition)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.