Human Gene REST (ENST00000619101.5) from GENCODE V44
Description: RE1 silencing transcription factor (from HGNC REST)
RefSeq Summary (NM_001193508): This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000619101.5
Gencode Gene: ENSG00000084093.19
Transcript (Including UTRs)
Position: hg38 chr4:56,909,016-56,935,844 Size: 26,829 Total Exon Count: 5 Strand: +
Coding Region
Position: hg38 chr4:56,910,639-56,927,655 Size: 17,017 Coding Exon Count: 3
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BC038985 - Homo sapiens, Similar to RE1-silencing transcription factor, clone IMAGE:5785778, mRNA, partial cds.U13879 - Human neuron-restrictive silencer factor mRNA, partial cds.JX896991 - Homo sapiens RE1-silencing transcription factor variant E1a/E2a/E2k (REST) mRNA, complete cds, alternatively spliced.JX896957 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/E4c (REST) mRNA, complete cds, alternatively spliced.JX896958 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4 (REST) mRNA, complete cds, alternatively spliced.JX896959 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E4 (REST) mRNA, partial cds, alternatively spliced.JX896960 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896962 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/N3c/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896963 - Homo sapiens RE1-silencing transcription factor variant E1a/N2a/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896964 - Homo sapiens RE1-silencing transcription factor variant E1a/N2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896965 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896961 - Homo sapiens RE1-silencing transcription factor variant E1a/E4 non-coding RNA (REST), complete sequence, alternatively spliced.KC117266 - Homo sapiens RE1-silencing transcription factor variant E1a/E2l/E2i/E3/E4j (REST) mRNA, complete cds, alternatively spliced.JX896971 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i (REST) mRNA, complete cds, alternatively spliced.JX896972 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E4b/E4d non-coding RNA (REST), complete sequence, alternatively spliced.JX896973 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E4i non-coding RNA (REST), complete sequence, alternatively spliced.JX896974 - Homo sapiens RE1-silencing transcription factor variant E1a/E4i non-coding RNA (REST), complete sequence, alternatively spliced.JX896975 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E2i/E3/E4i non-coding RNA (REST), complete sequence, alternatively spliced.JX896976 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E4f/E4i non-coding RNA (REST), complete sequence, alternatively spliced.JX896977 - Homo sapiens RE1-silencing transcription factor variant E1a/E2b/E4i non-coding RNA (REST), complete sequence, alternatively spliced.JX896978 - Homo sapiens RE1-silencing transcription factor variant E1a/E2d/E4g (REST) mRNA, complete cds, alternatively spliced.JX896979 - Homo sapiens RE1-silencing transcription factor variant E1a/E2e/E4h (REST) mRNA, complete cds, alternatively spliced.JX896980 - Homo sapiens RE1-silencing transcription factor variant E1a/E2f/E4e (REST) mRNA, complete cds, alternatively spliced.JX896984 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E5 (REST) mRNA, complete cds, alternatively spliced.JX896985 - Homo sapiens RE1-silencing transcription factor variant E1a/E3/E5 non-coding RNA (REST), complete sequence, alternatively spliced.JX896983 - Homo sapiens RE1-silencing transcription factor variant E1a/E2/E3/E5 (REST) mRNA, complete cds, alternatively spliced.KF429249 - Homo sapiens REST/EAPP fusion protein mRNA, complete cds.BC132859 - Homo sapiens RE1-silencing transcription factor, mRNA (cDNA clone MGC:164490 IMAGE:40146881), complete cds.BC136491 - Homo sapiens RE1-silencing transcription factor, mRNA (cDNA clone MGC:168103 IMAGE:9020480), complete cds.AB209750 - Homo sapiens mRNA for RE1-silencing transcription factor variant protein.BC017822 - Homo sapiens RE1-silencing transcription factor, mRNA (cDNA clone IMAGE:4690075), partial cds.JX896992 - Homo sapiens RE1-silencing transcription factor variant E1b/E2a/E2k (REST) mRNA, complete cds, alternatively spliced.JX896966 - Homo sapiens RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4 (REST) mRNA, complete cds, alternatively spliced.JX896968 - Homo sapiens RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4 (REST) mRNA, partial cds, alternatively spliced.JX896969 - Homo sapiens RE1-silencing transcription factor variant E1b/N1/E2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.KC117263 - Homo sapiens RE1-silencing transcription factor variant E1b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896981 - Homo sapiens RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i (REST) mRNA, complete cds, alternatively spliced.JX896982 - Homo sapiens RE1-silencing transcription factor variant E1b/E2e/E4h (REST) mRNA, complete cds, alternatively spliced.JX896989 - Homo sapiens RE1-silencing transcription factor variant E1b/E2/E3/E5 (REST) mRNA, complete cds, alternatively spliced.KC117265 - Homo sapiens RE1-silencing transcription factor variant E1b/E3/E5 non-coding RNA (REST), complete sequence, alternatively spliced.JX896993 - Homo sapiens RE1-silencing transcription factor variant E1c/E2a/E2k (REST) mRNA, complete cds, alternatively spliced.JX896970 - Homo sapiens RE1-silencing transcription factor variant E1c/E2g/E3/E4 (REST) mRNA, partial cds, alternatively spliced.KC117264 - Homo sapiens RE1-silencing transcription factor variant E1c/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JX896990 - Homo sapiens RE1-silencing transcription factor variant E1c/E2/E3/E5 (REST) mRNA, complete cds, alternatively spliced.U13877 - Human neural-restrictive silencer factor, splice variant mRNA, partial cds.U22314 - Human REST protein mRNA, complete cds.AB385046 - Synthetic construct DNA, clone: pF1KB5115, Homo sapiens REST gene for RE1-silencing transcription factor, complete cds, without stop codon, in Flexi system.JX896967 - Homo sapiens RE1-silencing transcription factor variant E1b/E2b/E2h/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.AF228045 - Homo sapiens truncated neuron restrictive silencer factor isoform (REST) mRNA, partial cds.KC117262 - Homo sapiens RE1-silencing transcription factor variant E1b/E2b/E3/E4 non-coding RNA (REST), complete sequence, alternatively spliced.JD042692 - Sequence 23716 from Patent EP1572962.DL490548 - Novel nucleic acids.U22680 - Human X2 box repressor mRNA, complete cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa05016 - Huntington's disease
Other Names for This Gene
Alternate Gene Symbols: A0A087X1C2, ENST00000619101.1, ENST00000619101.2, ENST00000619101.3, ENST00000619101.4, U22680, uc003hci.1, uc003hci.2, uc003hci.3, uc003hci.4, uc003hci.5UCSC ID: ENST00000619101.5RefSeq Accession: NM_001193508
GeneReviews for This Gene
GeneReviews article(s) related to gene REST:wilms-ov (Wilms Tumor Predisposition)
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.